血清抗苗勒管激素联合性激素检测在预测卵巢早衰中的临床意义

Clinical Significances of Serum Anti-miller Hormone and Sex Hormones Tests in Premature Ovarian Failure

目的探讨血清抗苗勒管激素(AMH)水平在早期预测卵巢早衰(POF)中的临床意义。方法用酶联免疫法测定41例POF组及37例围POF组妇女血清AMH水平,卵泡刺激素(FSH)、黄体生成素(LH)及雌二醇(E2)用电化学发光法检测,同时检测31例月经周期正常妇女作为对照组;并把对照组分为两个年龄段作了分析。结果血清AMH水平在月经正常组中最高,围POF组中明显下降,而在POF绝经组中最低,差异有统计学意义(P<0.05),FSH、LH水平在POF绝经组明显高于对照组,在围POF组中也略有升高。E2水平在POF绝经组中最低,与正常对照组比较有统计学意义(P<0.05),围POF组和正常组比较无明显差异(P>0.05);低年龄段妇女AMH水平高于大年龄段,之间有差异(P<0.05),FSH、LH及E2水平无差异(P>0.05)。结论 AMH水平随年龄增长逐渐下降,是卵巢功能衰退的敏感指标,联合FSH、LH及E2水平检测在早期预测卵巢早衰中有一定的价值。

Objective Study of serum anti -Mullefian hormone（AMH） levels in the early prediction of premature ovarian failure （POF） and its clinical significance. Methods The 41 patients in POF group and 37 patients in group POF women＇ s serum AMH level was measured by enzyme linked immunosorbent assay （ FSH）, follicle stimulating hormone, luteinizing hormone （LH） and estradiol （E2） measured by electrochemiluminescence detection at the same time,31 women with normal menstrual cycle as control group; and made a comparative analysis the group was divided into two age groups. Results The blood serum AMH level is highest in the menstruation normal group, encircles in the POF group to drop obviously, but is lowest in the POF menopause group, the difference has statistics sig- nificance （ P 〈 0.05 ）, Levels of FSH and LH in the POF menopause significantly higher than the control groups, wait POF group also increased slightly. The E2 level is lowest in the POF menopause group, compared with the normal control group was statistically signifi- cant （P 〈 0. 05 ）, Wait POF and normal groups not significantly different （P 〉 0.05 ） ;the low age section woman AMH level is higher than the great age section between different（ P 〈 0. 05 ） ,FSH ,LH and E2 level no difference（ P 〉 0.05）. Conclusion The AMH level grows along with the age drops gradually is a sensitive indicator of ovarian function decline,combined FSH and LH and E2 levels have a certain value in the early prediction of premature ovarian failure.