鼻息肉与上颌窦后鼻孔息肉变态反应差异的分析

Differences in results of allergen assay between patients with nasal polyps and antrochoanal polyps

目的对比鼻息肉(nasal polyps,NP)与上颌窦后鼻孔息肉(antrochoanal polyps,ACP)变应原检测结果的差异,以了解两种类型的鼻息肉疾病的病因及发病机制是否存在联系。方法回顾性分析42例NP患者及19例ACP患者的变应原皮肤点刺试验(SPT)的检测资料。结果 42例NP患者在44种变应原中至少出现1次变应原阳性的比例为47.6%(20例),而19例ACP患者中该比例为31.6%(6例);所有受试者对包括白色念珠菌、交链孢霉菌、松、咖喱、水果、肉类在内的等17种变应原均未出现过敏现象,而其他27种变应原在所有61例受试者中则至少出现了1次阳性结果。两组患者采用秩和检验对此27种变应原进行比较,结果显示ACP患者SPT试验的阴性率明显高于NP患者,差异具有统计学意义(Z=-5.0445,P<0.05)。结论 NP与ACP在变态反应学方面存在差异,两者的病因和发病机制可能有区别。

Objective To study the relation between etiology and pathogenesis of nasal polyps （NP） and antrochoanal polyps （ACP） via comparing the results of allergen assay in patients with these two types of nasal diseases. Methods 42 patients with NP and 19 with ACP were tested with 44 kinds of allergens by skin prick test （ SPT）. Their SPT results were analyzed retrospectively. Results The test results showed positive rate （ at least one allergen was positive） of 47.6% （20/42） in patients with NP, and 31.6% （6/19） in those with ACP. The test also showed negative results of 17 kinds of allergens in both groups, including candida albican, cross-linking spore mold, pine, curry, fruit, meat, et al. At least one of the other 27 kinds of allergens showed positive reaction in 26 of all the 61 cases. As for the 27 kinds of allergens, the negative rate of SPT test in ACP patients was obviously higher than that of NP patients, and the difference was statistically significant （ Z = - 5. 0445, P 〈 0.05 ）. Conclusions The etiology and pathogenesis of NP maybe different from those of ACP. Allergic reaction maybe one of the causes of NPand plays less significant role in ACP.