胚胎干细胞向造血细胞分化的研究进展

Hematopoietic Differentiation of Embryonic Stem Cells

胚胎干细胞(embryonic stem cells,ESCs)依靠其多能性(pluripotency)成为研究造血发生(hematopoiesis)的良好材料。近年来,ESCs向造血细胞体外分化系统的建立,为研究血液中不同类型细胞的发生发育提供了有用的研究模型。借助这些模型,使得我们对造血发生的研究逐步深入,我们对于造血系统的谱系分化有了更深刻的认识。该文对近年来ESCs向多种成熟血细胞的分化体系进行了总结与展望。

The embryonic stem cells （ESC） have been successfully used to study the development of the hematopoietic cell lineages. During the past decades, an increasing number of studies have demonstrated the in vitro hematopoietic differentiation systems of both mouse and human ESC cells, which provide useful tools for elucidating the regulation of hematopoietic development. In this review, we summarize the recent progress in the hematopoietic differentiation from pluripotent embryonic stem cells.