酒渣鼻病因及发病机制的研究进展

Advances in the etiology and pathogenesis of rosecea

酒渣鼻是一种慢性炎症性皮肤病，多发于中年患者面中部，表现潮红、持续性红斑、毛细血管扩张、丘疹、鼻赘等，有时还可累及眼。其病因和发病机制尚未完全了解，以往主要围绕光损、血管改变和微生物感染等提出假说，认为慢性紫外线辐射可破坏表皮屏障以及血管周围的结缔组织，导致皮肤脉管系统稳态异常，而多种微生物在酒渣鼻发展的作用尚待明确的证据。近来研究指出，固有免疫系统也参与其中，皮损中丝氨酸蛋白酶活性升高、抗菌肽的异常表达亦与之相关。

Rosacea is a chronic inflammatory skin disease occurring in the central region of the face with a predilection for middle-aged people. It is usually characterized by flushing, permanent erythema, telangiectasia, papules, rhinophyma, sometimes with the involvement of eyes. Its etiology and pathogenesis have not been completely understood. Past hypotheses on its pathogenesis were mainly focused on uhraviolet radiation, vascular abnormalities and infection by microorganisms such as Demodex folliculorum, and it was believed that chronic uhraviolet radiation could destroy epidermal barrier and perivascular connective tissue, resulting in vascular abnormalities. More evidences are needed to support the role of microbes in the development of rosacea. Recent molecular studies have suggested that innate immune system, increased serine protease activity and abnormal expression of antimicrobial peptides are all involved in the pathogenesis of