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APE/Ref-1在消化系统肿瘤中的研究进展

Advances in Study on APE/Ref-1 in Digestive System Tumors
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摘要 DNA碱基切除修复(BER)参与由各种原因导致的DNA损伤修复过程,是维持基因组DNA完整性的一个重要修复机制。脱嘌呤/脱嘧啶核酸内切酶/氧化还原因子-1(APE/Ref-1)是BER过程的关键酶之一,具有DNA修复、氧化还原激活、基因表达调控等多种生物学功能,近年研究显示APE/Ref-1与胃癌、结直肠癌、胰腺癌的发生关系密切。本文就APE/Ref-1在消化系统肿瘤中的研究进展作一综述。 DNA base excision repair（BER） is involved in the repair process of DNA damage due to all kinds of causes.It plays an important role in maintaining the integrity of genomic DNA.Apurinic / apyrimidinic endonuclease / redox factor-1（APE / Ref-1） is a key enzyme for BER.It has various biological functions such as DNA repair,oxidoreduction activation and regulation of gene expression.Recent studies demonstrated that APE / Ref-1 had a close association with gastric cancer,colorectal cancer and pancreatic cancer.This article reviewed the advances in study on APE / Ref-1 in digestive system tumor.
作者 宋军民 李琳 李岩
机构地区 中国医科大学附属盛京医院消化内科
出处 《胃肠病学》 2013年第6期374-377,共4页 Chinese Journal of Gastroenterology
关键词 DNA-(无嘌呤或无嘧啶位点)裂合酶 氧化还原因子-1 消化系统肿瘤 DNA修复 DNA-（Apurinic or Apyrimidinic Site） Lyase Redox Factor-1 Digestive System Neoplasms DNA Repair
分类号 R735 [医药卫生—肿瘤]
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胃肠病学
2013年 第6期

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