摘要
目的采用静息态功能磁共振成像研究性别对正常人脑边缘区功能连接的影响。方法对64名健康志愿者进行常规磁共振成像(MRI)、三维结构像及静息态脑功能成像扫描。将受试者分为男性组及女性组,手工勾画边缘区蒙片,进行全脑基于感兴趣区的功能连接计算。单组数据采用单样本t检验,成组数据采用协方差分析,年龄为协变量。结果男性组边缘区相关的功能连接位于双侧中扣带回、岛盖、岛叶、壳核、丘脑及杏仁核;女性组边缘区相关的功能连接脑区位于双侧颞横回、壳核、丘脑及杏仁核。男性组较女性组边缘区相关的功能连接增多的脑区位于右侧颞上回、颞中回及直回,功能连接减少的脑区位于左侧顶上小叶。结论边缘区的功能连接存在性别的一致性和差异性。
Objective To explore the impact of gender on the marginal division (MrD) of the neostriatum in healthy adults. Methods Conventional magnetic resonance imaging ( MRI), 3D structure images, and resting-state function MRI (rs-fMRI) were performed in 64 health adults, who were divided into male group ( n = 28) and female group (n = 26). MrD was defined using manual drawing on structure images, and was applied to the computation of functional connectivity maps. Single group data was performed with simple t test, and two groups data were performed with analysis of covariance with age as the covariance. Results The brain regions of functional connectivity related with MrD were located in bilateral middle cingnlate gyrus, rolandic opereulum, insula, putamen, thalamus and amygdala in male group, and in bilateral heschl gyms, putamen, thalamus and amygdala in female group. The brain regions with increased functional connectivity related with MrD were demon- strated in right superior temporal gyrus, middle temporal gyrus and gyrus rectus, and decreased in left superior parietal cortex in male group compared with that in female group. Conclusion The functional connectivity related with MrD shows certain gender-related consistency and difference in the brain of health adults.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2013年第3期294-298,共5页
Acta Academiae Medicinae Sinicae
基金
解放军总医院博士创新基金(10BCZ08)~~
关键词
边缘区
功能连接
性别
磁共振成像
marginal division of the neostriatum
functional connectivity
sex
magnetic resonance imaging