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β-arrestin在血管紧张素Ⅱ信号通路中的作用 被引量：1

Advancement of β-arrestin and angiotensinⅡ signal pathway
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摘要 对Arrestin家族的研究是当今生物学信号转导领域的热点之一。近年对肾素-血管紧张素系统(RAS)认识有重要突破,血管紧张素Ⅱ1型受体(AT1R)属于G蛋白偶联受体,当血管紧张素Ⅱ激活ATIR后,其下游除传统的G蛋白信号途径外,还有β-arrestin信号通路,两者相互独立。本文概括了近年来β-arrestin在血管紧张素Ⅱ信号通路中的研究进展,尤其β-arrestin依赖性信号通路。 Arrestin family has recently drawn much attention in signal transduction research, including RAS （renin-angiotensin-systerm）signaling. It has been found that there are two independent signal pathways following the activation of angiotensinⅡreceptor type 1 （AGT1R） by angiotensinⅡ （AngⅡ）：G-protein signal pathway and β-arrestin signal pathway. This review article summarizes the role of β-arrestin in Ang Ⅱsignal pathway, particularly focusing on β-arrestin signal pathway.
作者 赵莉芹 余晨
机构地区 同济大学医学院 同济大学附属同济医院肾脏科
出处 《肾脏病与透析肾移植杂志》 CAS CSCD 北大核心 2013年第3期254-257,共4页 Chinese Journal of Nephrology,Dialysis & Transplantation
关键词 Β-ARRESTIN 血管紧张素Ⅱ 血管紧张素Ⅱ1型受体 β -arrestin；AngiotensinⅡ；AT1R；
分类号 R363 [医药卫生—病理学]
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肾脏病与透析肾移植杂志
2013年 第3期

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