高迁移率族蛋白1与肾脏疾病

High mobility group box 1 protein and kidney diseases

高迁移率族蛋白1(HMGB1)作为一种重要的炎性介质,可通过炎症细胞的主动分泌和坏死细胞的被动释放进入胞外介导炎症反应。近年来,HMGB1在狼疮肾炎、ANCA相关性血管炎肾损害、急性肾损伤、间质性肾炎、肾脏缺血/再灌注损伤等发生发展过程中所发挥的重要作用备受关注,并对慢性肾脏病和透析患者的炎症、营养状态等有良好的指向作用,本文就相关的研究进展进行综述。

High mobility group protein B-1 （HMGB-1） is an important late inflammatory mediator.HMGB-1 could be actively excreted by inflammatory cells, and may also be passively released by the dying cells into the extracellular milieu, and then mediates the inflammation reaction. Recently, the role of HMGB1 in various kidney diseases is suffered much concern. Results from previous studies have demonstrated that HMGB-1 played a vital role in the pathogenesis and development of lupus nephritis, ANCA-associated vasculitis with renal manifestations, acute kidney injury, interstitial nephritis, renal ischemia-reperfusion injury, and it correlated with many markers of inflammation and malnutrition in CKD and dialysis patients. This review is focused on the recent progresses of HMGB-1 in kidney diseases.