基底细胞癌的共聚焦激光扫描显微镜图像特征

Confocal Laser Scanning Microscopic Features of Basal Cell Carcinoma

目的探讨基底细胞癌(BCC)的共聚焦激光扫描显微镜(CLSM)图像特征。方法对12例经病理活检确诊的BCC患者进行CLSM检测,分析BCC的CLSM图像特征。结果 12例患者皮损部位的表皮和/或真皮中均可见高折光细胞团块,其细胞拉长,呈轮辐状排列,8例瘤体内及其周边可见以单一核细胞为主的炎症细胞浸润,11例在瘤体内及其周边可见血管明显扭曲扩张。结论表皮及真皮内高折光细胞团块,其细胞拉长呈轮辐状排列是基底细胞癌的特征性CLSM图像特征,可作为CLSM诊断基底细胞癌的重要依据。

Objective To investigate the confocal laser scanning microscopic （CLSM） features of basal cell carcinoma （BCC）. Methods The lesions of 12 patients with BCC were examined using CLSM, and the CISM features were analyzed. Results A uniform bright, highly refractive, elongated population of basal cell carcinoma cells oriented along the same axis were present in all 12 patients with BCC. Abundant blood vessels demonstrating prominent tortuosity were seen in 11 patients. Prominent, predominantly mononuclear inflammatory infiltrate were seen in 8 patients. Conclusion Our results demonstrate that the uniform bright, highly refractive population of basal cell carcinoma cells with characteristic elongated nuclei oriented along the same axis may be the very important clues in the diagnosis of BCC with CLSM.