以鼻部结节及鼻腔扁平湿疣为体征的梅毒1例

One Syphilis Case with the Sign of Nasal Nodules and Condyloma Latum in Nasal Cavity

患者男,42岁。左侧鼻唇沟结节20d,鼻腔赘生物10d。皮肤科情况:左侧鼻唇沟处线状排列数个紫红色结节,左侧鼻腔前庭存在数个紫红色赘生物。快速血浆反应素试验(RPR)1:4(+),梅毒螺旋体血凝试验(TPPA)(+)。皮损组织病理示:表皮假上皮瘤样增生,真皮浅层可见大量浆细胞浸润。诊断:二期梅毒。予苄星青霉素240万U分两侧臀部肌注,1次/周,3周后结节消失,3个月后复查RPR(-)。

A 42-year-old male had been suffered from nodules on left nasolabial fold for 20 days, in left nasal cavity for 10 days. Dermatological examination showed that several claret-colored nodules on left nasolabial fold and in left nasal cavity. Rapid plasma regain assay （RPR） and treponema pallidum particle assay （TPPA） both appeared positive. Histopathology examination revealed epidermal pseudoepitheliomatous hyperplasia, infiltration of a large number of plasmoeytes in the superficial layer of dermis. The case was diagnosed as＂ sec- ondary syphilis＂. The nodules disappeared after three times of treatment with benzathine penicillin, and RPR appeared negative 3 months later.