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潜在的流感大流行病毒：H9N2禽流感病毒 被引量：15

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摘要 流感是一种由甲（A）、乙（B）和丙型（C）流感病毒引起的急性呼吸道传染病.根据甲型流感病毒的包膜糖蛋白,病毒可以分为1 ～16个血凝素（HA）和9个神经氨酸酶（NA）亚型,而这些均可从水禽体内分离出来[1].最近,人们又从蝙蝠的体内发现了H17亚型,但未能成功分离出病毒.按照病毒的致病性来分,可以将所有的H1-16亚型禽流感病毒分为高致病性、低致病性和无致病性禽流感病毒[2].至今为止,人们仅发现H5和H7两种高致病性禽流感病毒.H5、H9和H7等禽流感病毒被证实能够偶尔感染人[3].
作者 辛丽 舒跃龙
机构地区 中国疾病预防控制中心病毒病预防控制所
出处 《中华实验和临床病毒学杂志》 CAS CSCD 2013年第3期234-235,共2页 Chinese Journal of Experimental and Clinical Virology
关键词 高致病性禽流感病毒 流行病毒 急性呼吸道传染病 甲型流感病毒 包膜糖蛋白 神经氨酸酶 亚型 血凝素
分类号 R51 [医药卫生—内科学] R3 [医药卫生—基础医学]
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参考文献25

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同被引文献122

  • 1郭元吉.高致病性禽流感研究进展[J].中华实验和临床病毒学杂志,2006,20(2):90-93. 被引量：46
  • 2闻玉梅.禽流感病毒与人禽流感的研究进展[J].微生物与感染,2006,1(4):239-241. 被引量：5
  • 3Sun Y,Qin K,Wang Jyet al. High genetic compatibility andincreased pathogenicity of reassortants derived from avianH9N2 and pandemic H1N1/2009 influenza viruses [ J ].Proc Natl Acad Sci USA, 2011, 108:4164-4169.
  • 4Steel J, Lowen AC, Mubareka S, et al. Transmission of in-fluenza virus in a mammalian host is increased by PB2 ami-no acids 627K or 627E/701N[ J]. PLoS Pathog, 2009, 5 :el000252. doi; 10.1371/joumal. ppat. 1000252.
  • 5Mok CK, Yen HL, Yu MY, et al. Amino acid residues 253and 591 of the PB2 protein of avian influenza virus A H9N2contribute to mammalian pathogenesis[ J]. J Virol, 2011,85:9641-9645.
  • 6Xu C, Hu WB, Xu K, et al. Amino acids 473V and 598Pof PB1 from an avian-origin influenza A virus contribute topolymerase activity,especially in mammalian cells [ J ] ? JGen Virol, 2012, 93:531-540.
  • 7Yamayoshi S, Yamada S, Fukuyama S, et al. Virulence-af-fecting amino acid changes in the PA protein of H7N9 influ-enza A vimses[J]. J Virol, 2014, 88:3127-3134.
  • 8Hara K, Schmidt FI, Crow M, et al. Amino acid residuesin the N-terminal region of the PA subunit of influenza A vi-rus RNA polymerase play a critical role in protein stability,endonuclease activity, cap binding, and virion RNA pro-moter binding[J]. J Virol, 2006, 80:7789-7798.
  • 9Sun Y, Tan Y,Wei K, et al. Amino acid 316 of hemag-glutinin and the neuraminidase stalk length influence viru-lence of H9N2 influenza virus in chickens and mice [ J ]. JVirol, 2013, 87:2963-2968.
  • 10Liu D, Shi W, Shi Y,et al. Origin and diversity of novelavian influenza A H7N9 viruses causing human infection :phylogenetic,structural,and coalescent analyses [ J ].Lancet, 2013, 381:1926-1932.

引证文献15

二级引证文献52

中华实验和临床病毒学杂志
2013年 第3期

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