超重/肥胖患者高胰岛素血症与低钾周期性瘫痪的关系研究

The Relationship Between Hyperinsulinemia and Hypokalemic Periodic Paralysis in Overweight/Obesity Subjects

目的研究高胰岛素血症与超重/肥胖患者低钾性周期性瘫痪(低钾周瘫)的关系。方法以体质量超重或肥胖的散发型低钾周瘫患者作为病例组,测定其基础状态和进食标准餐后1～4h的血糖、血胰岛素、血钾水平,并与其性别、年龄、体质量指数均匹配的无低钾周瘫的超重/肥胖者(对照组)比较。结果病例组男性明显多于女性(男性14例、女性2例),初始发病年龄20～50岁不等。两组受试者血清胰岛素水平均在进餐后1h达峰值,同步血钾达谷值;病例组餐后1h胰岛素明显高于对照组,差异有统计学意义。病例组胰岛素曲线下面积及胰岛素曲线下面积/血钾曲线下面积明显高于对照组,差异有统计学意义。结论有高胰岛素血症的男性超重/肥胖者应警惕散发型低钾周性瘫的发生。

Objective To study the relationship between hyperinsulinemia and primary periodic paralysis in overweight/obesity people. Methods Overweight/obesity people with primary hypokalemie periodic paralysis were administrated as disease group. Serum potassium, insulin and glucose were analyzed at different time （0 h, 1 h, 2 h, 3 h, 4 h） after taking 100 g carbohydrates and the results were compared with that of control group matched by gender, age and body mass index （BMI）. Results ① Males were much more than females in disease group （14 males and 2 females）, the onset age ranged from 20 to 50 years old. ②Both the highest insulin level and the lowest potassium level appeared at one hour after taking the carbohydrates. And the highest insulin level of disease group was significant higher than that of control group. ③The area under the curve of insulin and insulin/potassium of disease group was significant higher than that of control group. Conclusion The postprandial hyperinsulinemia was an important factor in overweight/obesity people with hypokalemic periodic paralysis.