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足月产后绒毛膜癌10例临床分析

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摘要 目的分析足月产后绒毛膜癌患者的临床特征及预后,为其规范化治疗提供一定帮助。方法回顾性总结分析2007年01月至2011年12月在我院收治的10例足月产后绒毛膜癌患者的临床病理资料。结果①根据2000年国际妇产科联盟(FIGO)临床分期,10例患者中Ⅰ期2例,Ⅲ期7例,Ⅳ期1例。按照2000年FIGO预后评分系统评分,低危型2例,高危型8例。②所有患者均接受了联合化疗,4例患者因耐药而更换方案。2例患者接受化疗联合手术治疗。③9例患者获得完全缓解,随访6个月到5年,无疾病复发征象。1例自行停药后病情加重,经多方案治疗后仅获得部分缓解,再次自行停治疗半年后死亡。结论足月产后绒毛膜癌是一种少见的妊娠滋养细胞肿瘤,恶性程度高,耐药是提高治愈率的最大挑战。早期诊断、规范治疗可改善预后。
出处 《四川大学学报(医学版)》 CAS CSCD 北大核心 2013年第4期696-698,共3页 Journal of Sichuan University(Medical Sciences)
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  • 1Bagshawe KD, Dent J, Webb J. Hydatidiform mole in England and Wales 1973-1983. Lancet,1986;2(8508) :673-677.
  • 2雷呈志,向阳,万希润,杨隽钧,崔全才,冯凤芝,杨秀玉.足月产后绒毛膜癌患者的临床特征与预后分析[J].中华妇产科杂志,2006,41(11):752-755. 被引量:7
  • 3Smith HO, Kohorn E, Cole LA. Choriocarcinoma and gestational trophoblastic disease. Obstet Gynecol Clin North Am,2005;32(4) :661-684.
  • 4崔竹梅,杨秀玉,向阳,宋鸿钊,邵丽娜,李大兵.足月产后绒癌误诊分析[J].中国妇产科临床杂志,2001,2(1):22-24. 被引量:8
  • 5向阳.宋鸿钊滋养细胞肿瘤学.第3版.北京:人民卫生出版社,2011:84—86.
  • 6Ma v, Xiang Y, Wan XR, et al. The prognostic analysis of 123 postpartum choriocarcinoma cases. Int J Gynecol Cancer, 2008;18(5) :1097-110l.
  • 7Powles T, Young A, Sanitt A, et al , The significance of the time interval between antecedent pregnancy and diagnosis of high-risk gestational trophoblastic tumours. Br J Cancer, 2006; 95(9) :1145-1147.
  • 8郑伟,谢幸,陈毓华,孙旬仙.足月产后绒癌37例临床分析[J].实用妇科与产科杂志,1991,7(6):315-316. 被引量:2
  • 9Bianconi Ml , Otero S, Moscheni 0, et al . Gestational trophoblastic disease: a 21-year review of the clinical experience at an Argentinean public hospital. J Reprod Med , 2012;57(7-8) :341-349.
  • 10Cagayan MS. High-risk metastatic gestational trophoblastic neoplasia. Primary management with EMA-CO (etoposide, methotrexate, actinomycin D, cyclophosphamide and vincristine) chemotherapy. J Reprod Med,2012;57(5-6) :231- 236.

二级参考文献43

  • 1孙崟,向阳,万希润,杨秀玉.绒毛膜癌复发的影响因素分析[J].中华妇产科杂志,2006,41(5):329-332. 被引量:7
  • 2[4]宋鸿钊,吴葆桢,唐敏一,等.滋养细胞肿瘤的诊断和治疗.第1版.北京:人民卫生出版社,1983,102.
  • 3[1]Utoguchi N, Chandorkar G A, Avery M, et al. Functional expression of P-glycoprotein in primary culture of human cytotrophoblasts and BeWo cells[J]. Reprod Toxicol,2000,14(3) :217 - 224.
  • 4[2]Ushigome F, Takanaga H, Matsuo H, et al. Human placental transport of vinblastine,vincristine, digoxin and progesterone: contribution of P-glycoprotein[J]. Eur J Pharmacol.2000,408(1) :1 - 10.
  • 5[3]Sood A K, Sorosky J I, Squatrito R C, et al. Cyclosporin-A reverses chemoresistance in patients with gynecologic malignancies[J]. Neoplasia, 1999,1 (2): 118 - 122.
  • 6[4]Denboer M L, Pieters R, Kazemier K M, et al. Different expression of glutathione S-transferase alpha, mu and pi in childhood acute lymphoblastic and myeloid leukaemia [ J ]. Br J Haematol, 1999,104(2) :321 - 327.
  • 7[5]O' Brien M, Kruh G D, Tew K D. The influence of coordinate overexpression of glutathione phase Ⅱdetoxification gene products on drug resistance[J]. J Pharmacol Exp Ther,2000,294(2) :480 - 487.
  • 8[6]Pascolo L, Fernetti C, Garcia M M V, et al. Mechanisms for the transport of unconjugated bilirubin in human trophoblastic BeWo cells[J]. FEBS Lett,2001,495(1-2) :94 - 99.
  • 9[7]Kihara C, Seki T, Furukawa Y, et al. Mutations in zinc-binding domains of p53 as a prognostic marker of esophageal-cancer patients[J].Jpn J Cancer Res,2000,91(2) :190 - 198.
  • 10[8]McDonald A C, Brown R. Induction of p53-dependent and p53-independent cellular responses by topoisomerase 1 inhibitors[J]. Br J Cancer, 1998,78(6) :745 - 751.

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