摘要
目的:观察松花粉预防和延缓腮腺组织衰老IGF-I在腮腺导管细胞中的表达。方法:D-半乳糖连续腹腔注射制作亚急性衰老雄性大鼠模型,采用免疫组织化学方法(SP法)观察不同剂量的松花粉对衰老的腮腺组织IGF-I表达的影响。结果:IGF-I在腮腺组织广泛表达,D-半乳糖所致亚急性衰老大鼠模型组IGF-1的表达明显下降,与正常对照组比较差异显著(P<0.01);而经松花粉给药后IGF-I的表达明显上升,其中预防中剂量组效果明显。结论:松花粉具有改善衰老雄性大鼠腮腺功能紊乱,预防和延缓腮腺组织衰老的作用。
Objective： To observe the expression of IGFI during pollen pini preventing and delaying parotid tissues from getting senescent. Method： Made rat models with subacute senility by means of continu ous intraperitoneal injection with Dgalactosum and observed the effects of pollen pini of different on the ex pression of epidermal growth factor receptor（ IGFI ） in senescent parotid tissues. Results： IGFI was ex pressed extensively in parotid tissues j with the expression of IGFI in the rat model group with subacute se nility caused by Dgalactosum fallen remarkably and shown a remarkable difference compared with the nor mal control group （ P〈0.01 ） ; but after pollen pini was given into the senescent parotid tissues, the expres sion of IGFI especially that in the medium did group, rose remarkably. Conclusion：Pollen pini had the effect of relieving the disorder of parotid tissues in senescent male rats and preventing and delaying their pa rotid tissues from getting senescent.
出处
《河北医学》
CAS
2013年第8期1121-1123,共3页
Hebei Medicine
基金
河北省科技厅指令性课题(0627611033)
