抗抑郁药物5-羟色胺再摄取抑制剂对患者多脏器功能指标及血液学指标的影响

Influence of the Antidepressant of 5-Selective Serotonin Reuptake Inhibitor on the Indexes of Multiple Organ Function and Hematology of the Patients

目的:探讨现行抗抑郁药对抑郁症患者多脏器功能相关指标的影响以及对血液学指标的影响。方法:以现阶段临床一线抗抑郁药选择性5-HT再摄取抑制药(selective serotonin reuptakeinhibitor,SSRI)为研究对象,将是否使用SSRI药物作为分组依据,将抑郁症患者划分为SSRI治疗组和对照组,通过对两组患者进行多脏器功能检测的和血液学检测,比较两组人群在在这些指标结果上的差异,得出SSRI是否对抑郁患者脏器及凝血功能造成影响的结论。结果:两组患者在反映肝功能的指标天冬氨酸转氨酶(AST)及谷丙转氨酶(ALT)的比较上有差异(P<0.05);SSRI治疗组的红细胞数和血小板计数均低于对照组((P<0.05),其它多器官功能指标在两组的比较上差异无统计学意义(P>0.05)。结论:现行一线抗抑郁药物SSRI可能会影响患者的肝功能和诱导凝血障碍。需要长期服用SSRI的患者需要定期监测肝功和血凝相关指标。

Objective： To investigate the influence of the current antidepressants on the relevant indexes of the function of multiple organs and the hematological index of the patients with depression. Method. To choose the clinical first-line antidepressant of 5-selective serotonin reuptake inhibitor （SSRI ） as the object of the research, and to be whether to use the drug of SSRI as the basis of the group, then the patients with depression were divided into the group of SSRI treated and the control group. The differences of the results of those indicators that were obtained through testing for the function of multiple organ and for the hematology of the two groups of patients were compared, and then came to a conclusion whether SSRI influence on the function of organs and coagulation in depressive patients. Result： There was a difference （ P〈0.05 ） in the comparion of aspartate aminotransferase （ AST ） and alanine aminotransferase（ ALT } that reflect the index of of the liver function of patients in two groups; both the number of red blood cells and the counts of the platelets in SSRI treated group were less than in the control group（ P〈0.05 ） ; There is no statistical signifi- cance { P〉0.05 ） difference after the comparion of the indexes of the function in other multiple organs of the two groups. Conclusion： The current first-line antidepressant drug of SSRI may influence the function of the liver of the patients and induce coagulation disorder. It suggests that the patients that long-term taking of SS- RI should regularly monitor the function of the liver and the relevant index of blood coagulation.