药物保守治疗宫颈上皮内瘤变Ⅱ级疗效观察

Observation on Curative Effect of Cervical Intraepithelial Neoplasia GradeⅡ Treated by Medicine

目的:评价保妇康栓药物保守治疗宫颈上皮内瘤变Ⅱ级的疗效。方法:回顾性分析我院2006年至2010年间经阴道镜下宫颈多点活检诊断为CINⅡ并选择药物保守治疗的26例患者,分为使用保妇康栓组及干扰素栓组,比较两种药物治疗后随访期间的疗效。结果:经药物保守治疗病变逆转9例,其中7例为保妇康栓治疗组,2例为干扰素栓治疗组,随访2-6年未复发,17例患者随访期间改为LEEP手术治疗,保妇康栓与干扰素栓组分别为7例与10例。两组间的病变逆转率、病变持续率、病变进展率相比无统计学意义。结论:CINⅡ患者选择保妇康栓药物治疗,可促进病变逆转,但需要较长时间的随诊。

Objective： To evaluate the effect of conservative medication treatment in cervical intraepi thelial neoplasia grade Ⅱ. Method： Retrospective analysed 26 patients diagnosed CIN II by biopsy under eoloposeopy and ehosen to be treated with medieation treatment, and compared the treatment during observa tion period. Result： 9 cases were sueeessfully reversed by medication, 7 cases were treated by Baofukang suppository, 2 cases were treated by interferon suppository, and no recurrence occurred ranged from 2 to 6 years, 17 patients chose LEEP in followup, 7 cases were treated by Baofukang suppository, 10 cases were treated by interferon suppository. The lesion reversal rate, lesion sustained rate, and lesion progression rate showed no statistical significance. Conclusion： Conservative medication treatment can promote lesion rever sal in CIN Ⅱ, but need longtime follow up.