摘要
目的:以PEG400、甘油为内容物,考察辅料对中药软胶囊稳定性的影响。方法:采用加速试验3个月,考察内容物的甲醛含量变化及对囊壳崩解度影响。结果:PEG400组甲醛含量在3个月明显增长,而甘油组则基本无变化;甘油的囊壳崩解度符合规定,但是PEG400在70天检测不合格。结论:辅料产生的甲醛对软胶囊的崩解度有一定影响。
Objective： As PEG400 and glycerol to be content, to investigate accessory effect on stabilities of Chinese medicine soft capsule containing. Methods： The accelerated experiment was used, tested the content of formaldehyde and disintegration of soft capsule. Results： The formaldehyde content of PEG400 group increased significantly during 3 months while the glycerol group was barely stable; the disintegration of PEG400 group was below standard after the 70th days while e the glycerol group was fit. Conclu- sion： The content of formaldehyde from accessory show the effect on the disintegration of soft capsule.
出处
《中国民族民间医药》
2013年第11期53-54,共2页
Chinese Journal of Ethnomedicine and Ethnopharmacy
关键词
辅料
软胶囊
甲醛
稳定性
accessory
soft capsule
formaldehyde
stabilitis
