中西医结合治疗乳腺增生的Meta分析

Meta-analysis on Efficacy of Combination of Traditional Chinese and Western Medicine in Treatment with Breast Hyperplasia

目的应用Meta分析评价中西医结合治疗乳腺增生的总体疗效及同单纯西药或中药相比较。方法计算机检索中国学位论文全文数据库,维普数据库,MEDLINE;手工检索纳入试验的所有参考文献,比较中西医结合治疗与西药治疗的随机对照试验。对纳入研究的文献质量进行Meta分析。结果检索到符合纳入标准的临床对照试验文献7篇。Meta分析显示,OR合并=3.87,OR合并95%CI=2.75～5.43,合并效应的检验Z=7.79(P<0.00001)说明差异有统计学意义,中西医结合疗法治疗乳腺增生比单纯中药或西药治疗效果好。结论中西医结合疗法治疗乳腺增生比单纯中药或西药治疗的疗效要好,能明显改善临床症状。

Objective Application of the Meta-analysis of treatment on breast hyperplasia to evaluate combination of traditional Chinese and western medicine with western or Chinese medicine only. Methods Databases included：full paper database of Chinese excellent dissertations by doctors and masters,VIP,MEDLINE. Reference lists of trials were hand-searched. Published randomized controlled trials （RCTs） whether blind or unblind. Treatment was integration of traditional Chinese medicine （TCM） . Controls were western medicine. Data were extracted independently by 2 reviewers and Meta-analysis was performed by RevManS. 0 software obtained from the Cochrane collaboration. Results 7 randomized trials were included. Compared with the eontrolgroup, the combined outcome of combination of traditional Chinese and western medicine was effective to breast hyperplasia [ OR 3.87,95% CI（2. 75,5.43） ,P 〈 0. 00001 ]. Conclusion Combination of traditional Chinese and western medicine had better efficacy to patients with breast hyperplasia than western or Chinese medicine only.