性激素测定对多囊卵巢综合征的诊断与治疗的临床意义

Clinical significance of analyzing the endocrine hormone in the diagnosis and curative effects of polycystic ovary syndrome

目的观察性激素作为多囊卵巢综合征(PCOS)患者的诊断及治疗前后的临床意义。方法选择我院2012年3月至2013年2月收治的90例PCOS患者和30名健康者(对照组),采用免疫化学发光测定其血清睾酮、黄体生成素(LH)、促卵泡生成素(FSH)、胰岛素(INS)水平,并对结果进行统计学分析。结果①肝郁痰阻患者睾酮、LH/FSH>2与对照组比较差异有统计学意义,治疗后下降。②脾炎痰盛患者INS水平与对照组比较差异有统计学意义,治疗后下降。③肾炎痰凝患者睾酮、INS与对照组比较差异有统计学意义,治疗后下降。结论血清内分泌激素在PCOS的诊断与疗效观察中起重要的作用,PCOS患者具有高雄激素、高INS。治疗后肝郁痰阻者睾酮,LH/FSH>2显著下降,脾炎痰盛者空腹INS下降,肾炎痰凝者睾酮和空腹INS下降显著。

Objective To analyze the effect of endocrine hormone to polycystic ovary syndrome （PCOS） patients before and after the observation and clinical significance. Methods Ninety patients with PCOS and 30 healthy subjects （control group）, admitted in March 2012 to February 2013 in our hospital, the use of chemilumineseenee for deter- mination of serum testosterone （T）, luteinizing hormone （LH）, follicle stimulating hormone （FSH）, insulin levels （INS）, and results were analyzed statistically. Results ① Liver depression in patients with testosterone, LH/FSH 〉2 decreased and had a significant difference compared witn the control group after treatment. ② Spleen inflammation in patients with insulin levels declined and control group had significant differences compared witn the control group after treatment. ③ Type of nephritis in patients with testosterone, insulin decreased after treatment and had significant differ- ences compared with the control group. Conclusion Serum endocrine hormones play an important role in the diagnosis of PCOS and curative effects of PCOS with hyperandrogenism, insulin. Liver depression testosterone, LH/FSH 〉2 was significantly decreased, spleen inflammation type fasting insulin decreased, the nephritis testosterone and fasting insulin was significantly decreased after treatment.