氯压胍对大鼠血浆肾素活性的影响与孤束核的关系

Relationship between nucleus tractus solitraii and effect of guanabenz on plasma renin activity in anesthetized rats

弧束核(NTS)内注射微量氯压胍(GB)0.5μg及iv GD10μg/kg显著降低血浆肾素活性,同时降低血压,减慢心率。此结果提示:GB产生中枢性降低血浆肾素和降压作用,与激动NTS肾上腺素α_2受体有关。

Microinjection of guanabenz (GB)500ng into the nucleus tractus solitrarii(NTS) or iv GB 10μg/kg significantly reduced plasma renin activity (PRA), blood pressure and heart rate. These findings suggest that the inhibitory action of GB on PRA is related to the activation of alpha2 abrenoceptor in the NTS.