血清褪黑素水平与强直性脊柱炎疾病活动性之间的相关性研究

A research on correlation between serum melatonin level and disease activity of ankylosing spondylitis

目的探讨强直性脊柱炎(AS)患者血清褪黑素(MLT)水平与患者疾病活动性之间的相关性。方法 40例AS患者和40例非AS健康志愿者纳入研究。采用Bath强直性脊柱炎疾病活动指数(BASDAI)评估AS组患者的疾病活动程度,采用Bath强直性脊柱炎功能指数(BASFI)评估AS组患者的功能损害程度。采用所有研究对象的血液标本,测定其红细胞降沉率(ESR)、C反应蛋白(CRP)及血清MLT水平。结果 AS患者的ESR、CRP及血清MLT水平显著高于健康对照组,差异有统计学意义(P<0.01)。活动性AS患者(BASDAI≥40)的ESR(P=0.015)、CRP(P=0.012)以及BASFI(P=0.0016)显著高于非活动性AS患者(BASDAI<40);活动性与非活动性AS患者的血清MLT水平分别为(39.7±6.2)、(35.2±3.5)pg/mL,差异有统计学意义(P=0.011)。血清MLT水平与AS患者的BASDAI、BASFI及CRP呈正相关,但与ESR水平或病程无相关性。结论血清MLT的水平变化可反映AS患者的疾病活动性。

Objective To investigate the correlation between serum melatonin（MLT） level of patients with ankylosing spondylitis（AS） and the disease activities.Methods 40 patients with AS and 40 healthy volunteers without AS were enrolled in the study.Disease activities of patients with AS were evaluated by using Bath ankylosing spondylitis disease activity index（BASDAI） and their functional damage degrees were estimated by using Bath ankylosing spondylitis functional index（BASFI）.Serum samples from all study objects were subjected to detection of erythrocyte sedimentation rate（ESR）,C-reactive protein （CRP） and serum MLT levels.Results Serum ESR,CRP and MLT levels of patients with AS were all markedly higher than those in health control group with statistically significant differences（P0.01）.ESR（P=0.015）,CRP（P=0.012） and BASFI（P=0.001 6） of patients with active AS（BASDAI≥40） were significantly higher than those in patients with inactive AS（BASDAI40）.The serum MLT levels of patients with active and inactive AS were （39.7±6.2）,（35.2±3.5） pg/mL,respectively,with statistically significant differences（P=0.011）.Serum MLT levels were positively correlated with BASDAI,BASFI and CRP of patients with AS,whereas no correlation were found between it with ESR levels or disease duration.Conclusion Changes of serum MLT levels may indicate disease activity of patients with AS.