缺血修饰清蛋白在儿童心肌损伤中的临床价值研究

The clinical value of ischemia modified albumin in diagnosing the myocardial damage in children

目的探讨缺血修饰清蛋白(IMA)在儿童心肌损伤中的临床价值。方法选取在2012年2～10月武汉市儿童医院儿科收治的心肌损伤的患儿143例、心律失常的患儿113例、单纯呼吸道感染的患儿144例,健康儿童104例。采集静脉血,应用清蛋白钴结合试验,采用比色法测定血清IMA水平,应用SPSS17.0软件分析各组血清IMA浓度及阳性率。结果心肌损伤组血清IMA水平为(98.23±20.87)U/mL,明显高于健康对照组[(75.82±10.23)U/mL]、心律失常组[(72.45±13.36)U/mL]以及单纯呼吸道感染组[(78.24±22.35)U/mL](P<0.05);心肌损伤组血清IMA的阳性率(75.52%)也显著高于其他3组(11.54%、7.08%、16.67%)(P<0.05)。结论血清IMA对心肌损伤患儿的早期诊断具有重要临床意义。

Objective To study the clinical value of ischemia modified albumin（IMA） in diagnosing the myocardial damage in children.Methods 400 children were selected in this study,including 143 children of myocardial damage,113 children of arrhythmia,144 children of only respiratory tract infection and 104 normal children,during the period from February to October 2012 in Children′s Hospital of Wuhan.The venous blood of all the subjects were collected and the serum level of IMA were detected using the albumin cobalt bind test. The data were analyzed using SPSS 17.0 software.Results The level and the positive rate of IMA in the myocardial damage group （98.23±20.87） U/mL,75.52% are significantly higher than the control group（75.82±10.23） U/mL,11.54%,the arrhythmia group （72.45±13.36） U/mL,7.08% and the only respiratory tract infection group （78.24±22.35） U/mL,16.67%（P0.05）.Conclusion The detection of the serum IMA is promising in diagnosing the myocardial damage in children.