氯丙嗪和利培酮对精神分裂症患者血糖调节功能的影响

Effect of chlorpromazine and risperidone on regulation of blood glucose of schizophrenic

目的探讨氯丙嗪和利培酮对精神分裂症患者血糖调节功能的影响。方法 60例精神分裂症患者随机均分为氯丙嗪组和利培酮组,比较2组治疗前、后血糖调节功能变化情况。结果 2组患者空腹血糖组内比较均有显著变化,氯丙嗪组升高更明显。2h-PG2组均从治疗3个月后升高,且氯丙嗪组升高更明显。2h-PBG氯丙嗪组从治疗3个月后开始明显升高,利培酮组从治疗6个月后开始明显升高。HbA1c氯丙嗪组从治疗6个月后明显升高,利培酮组变化不明显。2组患者治疗1年后,发生IGR的例数比较,差异有统计学意义(P<0.05)。结论氯丙嗪较利培酮更早且更易引起精神分裂症患者血糖调节异常。

Objective To discuss the effect of chlorpromazine and risperidone on regulation of blood glucose of schizophrenic.Methods 60 cases with schizophrenia were randomly divided into chlorpromazine group and risperidone group.The regulation of blood glucose were compared between two groups before and after treatment.Results The levels of FBG in two groups increased obviously,and the chlorpromazine group increased more.The levels of 2h-PG in two groups increased after 3 months;The levels of 2h-PBG in chlorpromazine group increased after 3 months,and risperidone group increased after 6 months;The levels of HbA1c in chlorpromazine group increased after 6 months,risperidone group increased unconspicuously.After 1 year,The number of IGR cases in two groups had significant difference（P0.05）.Conclusion The effect of chlorpromazine on regulation of blood glucose is more obvious and earlier than risperidone.