子宫内膜增生过长与内膜腺癌细胞核结构成分分析

Stereologic morphometric study on nuclei components of endometrial hyperplasia and adenocarcinoma

用体视学方法对正常增殖期子宫内膜、囊腺型和腺瘤型增生过长及高分化内膜腺癌各5例腺上皮细胞核的超微结构进行形态计量分析。结果表明:在子宫内膜细胞癌变过程中最主要的变化为核浆比、核仁体积及常染色质体密度的增大,这些改变可以作为病理学诊断较有意义的参考指标。

The ultrastructure of gland cell nuclei of normal proliferative endometrium,cystic and adenomatous hyperplasia, and well-differentiated adenocarcinoma ( 5 cases for each group ) had been studied by stereologic morphometry. The results showed: malignant evolution of endometrial cells was characterized by the increase of nucleocytoplasmic ratio and volume of nucleoli as well as volumetric density of eu-chromatin. These features could be served as relatively sensitive criteria for recognizing malignancy, but increase of nuclear size could not.