摘要
人类白细胞抗原G(HLA-G)作为非经典HLA-Ⅰ类分子,以膜结合型和胞质可溶型2类形式存在。HLA-G由于其独特结构和生物学功能,在母胎界面的免疫耐受中发挥重要作用,既能调节正常的妊娠,还与部分病理性妊娠密切相关。笔者拟就HLA-G在复发性自然流产中的研究进展,综述如下。
As non-classical molecular of human leukocyte antigen Ⅰ,human leukocyte antigen G（HLA-G）exist by two isoforms which are membrane-bounded isoform and cytoplasmic soluble isoform.Due to its unique conformation and biologic function,HLA-G plays important role in the maternal-fetus immunologic tolerance,it can regulate the normal process of pregnancy,and also closely associated with some pathological pregnancy.This paper discusses the progress research of HLA-G in recurrent miscarriage.
出处
《中华妇幼临床医学杂志（电子版）》
CAS
2013年第3期335-338,共4页
Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)
基金
国家自然科学基金资助项目(30973461)~~
