期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

生长抑制因子家族在组蛋白乙酰化修饰作用的研究进展 被引量：1

下载PDF
导出
摘要 生长抑制因子(inhibitor of growth,ING)家族成员是候选的抑癌基因。ING蛋白能够与组蛋白乙酰基转移酶、去乙酰化酶等相互结合并形成复合物,该类复合物具有识别组蛋白密码、参与染色体重构、调节特定基因的表达、与p53协同作用、诱导细胞凋亡等作用。本文就生长抑制因子家族参与组蛋白修饰的作用做一综述。
作者 张菊秋 叶玉兰 常卫柱
机构地区 吉林省吉林市昌邑区桦皮厂镇中心卫生院 吉林省永吉县医院
出处 《中国医学创新》 CAS 2013年第19期161-163,共3页 Medical Innovation of China
关键词 生长抑制因子 组蛋白乙酰基转移酶 组蛋白去乙酰化酶
分类号 R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献20

  • 1He G H,Helbing C C,Wagner M J,et al.Phylogenetic analysis of the ING family of PHD finger proteins[J].Mol Biol Evol,2005,22(1):104-116.
  • 2Doyon Y,Cayrou C,Ullah M,et al.ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation[J].Mol Cell,2006,21(1):51-64.
  • 3Soliman M A,Riabowol K.After a decade of study-ING,a PHD for a versatile family of proteins[J].Trends Biochem Sci,2007,32(11):509-519.
  • 4Blander G,Guarente L.The Sir2family of protein deacetylases[J].Annu Rev Biochem,2004,73(5):417-435.
  • 5Grant P A,Berger S L.Histone acetyltransferase complexes.Semin Cell Dev Biol,1999,10:169-177.
  • 6Kuzmichev A,Zhang Y,Erdjument-Bromage H,et al.Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)[J].Mol Cell Biol,2002,22(1):835-848.
  • 7Xin H,Yoon H G,Singh P B,et al.Components of a pathway maintaining histone modification and heterochromatin protein1binding at the pericentric heterochromatin in mammalian cells[J].J Biol Chem,2004,279(1):9539-9546.
  • 8Meehan W J,Samant R S,Hopper J E,et al.Breast cancer metastasis suppressor1(BRMS1)forms complexes with retinoblastoma-bindingprotein1(RBP1)and the mSin3histone deacetylase complex and represses transcription[J].J Biol Chem,2004,279(1):1562-1569.
  • 9Kumamoto K,Fujita K,Kurotani R,et al.ING2is up-regulated in colon cancer and increases invasion by enhanced MMP13expression[J].Int J Can,2009,8(1):456-458.
  • 10Leeman M F,Curran S,Murray G I.The structure,regulation,and function of human matrix metalloproteinase-13[J].Crit Rev Biochem Mol Biol,2002,37(1):149-166.

同被引文献38

  • 1Hu RM, Han ZG, Song HD, et al. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning [ J ]. Proe Natl Aead Sei USA ,2000,97 ( 17 ) :9543-9548.
  • 2Shiseki M, Nagashima M, Pedeux RM, et al. p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity[ J]. Cancer Res, 2003,63 ( 10 ) : 2373-2378.
  • 3Gong W, Suzuki K, Russell M, et al. Function of the ING family of PHD proteins in cancer [ J]. Int J Bioehem Cell Biol, 2005,37 (5) : 1054-1065.
  • 4Doyou Y, Cayrou C, Ullah M,et al. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation[ J]. Mol Ce11,2006,21 (1) :51-64.
  • 5Li XH, Kikuehi K, Zheng Y, et al. Downregulation and transloca- tion of nuclear ING4 is correlated with tumorigenesis and progres- sion of head and neck squamous cell carcinoma [ J ]. Oral Oneol, 2011,47(3) :217-223.
  • 6Unoki M, Kumamoto K,Takenoshita S, et al. Reviewing the current classification of inhibitor of growth family proteins[ J]. Cancer Sei, 2009,100(7) :1173-1179.
  • 7He GH, Helbing CC, Wagner MJ, et al. Phylogenetic analysis of the ING family of PHD finger proteins [ J ]. Mol Biol Evol,2005, 22(1) :104-116.
  • 8Nanding A,Tang L,Cai L,et ai. Low ING4 protein expression de- tected by paraffin-section immunohistochemistry is associated with poor prognosis is untreated patients with gastrointestinal stromal tumors[ J]. Gastric Cancer,2014,17 ( 1 ) :87-96.
  • 9Shi XB ,Tao H,Kay L,et al. ING2 PHD domain links histone H3 lysine methylation to active gene repression [ J ]. Nature, 2006, 442(7098) :96-99.
  • 10Poon IK, Jans DA. Regulation of nuclear transport:central role in development and transformation [ J]. Traffic, 2005,6 ( 3 ) : 173- 186.

引证文献1

二级引证文献2

中国医学创新
2013年 第19期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部