局部晚期宫颈癌新辅助化疗的临床疗效分析

Clinical Analysis of Neoadjuvant Chemotherapy in Locally Advanced Cervical Cancer

目的:观察局部晚期宫颈癌新辅助化疗的临床治疗效果。方法:选取笔者所在医院2010-2012年收治的局部晚期宫颈癌患者20例,其中Ⅰb2期的患者6例,Ⅱa期的患者12例,Ⅱb期患者2例。通过2个疗程的紫衫醇联合卡铂化疗方案静脉化疗之后,对所有患者都进行宫颈癌根治术,观察分析其治疗效果。结果:化疗的总有效率为70.0%(14/20);Ⅰb2期的总有效率为66.7%(4/6),Ⅱa期的总有效率为66.7%(8/12),Ⅱb期的总有效率为50.0%(1/2),三组间比较差异无统计学意义(P>0.05)。鳞癌的有效率为66.7%(8/12),腺鳞癌的有效率为25.0%(1/4),腺癌的有效率为50.0%(2/4),鳞癌和腺鳞癌的疗效比较差异有统计学意义(P<0.05)。结论:紫杉醇联合卡铂化疗,对于局部晚期宫颈癌的治疗有显著的效果,且有很好的耐受性,值得临床推广。

Objective： To observe the clinical effects of new adjuvant chemotherapy on locally advanced carcinoma of the cervix.Methods： Select the author＇s hospital in 2010-2012 treated 20 patients with locally advanced cervical cancer, including Ⅰb2 period 6 cases, Ⅱ a period 12 cases, Ⅱb period 2 cases. Through two course of purple shirts alcohol plus carboplatin chemotherapy regimens after intravenous chemotherapy, for all patients with cervical cancer radical, observation analysis of the therapeutic effect.Results： Chemotherapy, the total effective rate was 70.0%（14/20）; I b2 phase of the total effective rate was 66.7%（4/6）, Ⅱ a period of the total effective rate was 66.7%（8/12）, lIb of the total effective rate was 50.0%（1/2）, the difference among three groups had no statistical significance（P〉0.05）. Squamous cell carcinomas of the effective rate was 66.7%（8/12）, effective rate was 25.0%（1/4） of gland scale cancer, gland cancer the effective rate was 50.0%（2/4）, squamous carcinoma and the curative effect of gland scale cancer comparative difference was statistically significant（P〈0.05）. Conclusion： paclitaxel plus carboplatin chemotherapy for locally advanced cervical cancer treatment has a significant effect, and have very good tolerance, worth clinical promotion.