痰热清注射液联合阿奇霉素治疗小儿支原体肺炎的临床观察

Clinical observation of Tanreqing injection combined with azithromycin as sequential therapy for children with mycoplasma pneumonia

目的探讨痰热清注射液联合阿奇霉素序贯治疗小儿支原体肺炎的临床疗效。方法将88例小儿支原体肺炎患者随机分入对照组与观察组,给予42例对照组患者阿奇霉素序贯治疗,46例观察组患者接受痰热清注射液联合阿奇霉素序贯治疗。比较两组临床疗效、不良反应发生率及血清超敏C-反应蛋白(hs-CRP)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)的差别。结果观察组与对照组治疗总有效率分别为95.7%和69.0%,差别具有统计学意义(P<0.05);观察组不良反应发生率显著少于对照组(21.7%vs 88.1%,P<0.05);两组治疗后血清hs-CRP、IL-6和TNF-α水平较治疗前均显著降低(P<0.05),但两组间无显著差别(P>0.05)。结论痰热清注射液联合阿奇霉素序贯治疗小儿支原体肺炎可显著提高临床疗效,减少不良反应。

Objective To explore the clinical effect of tanreqing injection combined with azithromycin as sequential therapy for children with mycoplasma pneumonia.Methods 88 children with mycoplasma pneumonia were randomly divided into the control group（n =42） and the experience group（n =46）.The control group was given azithromycin sequential therapy,and the experience group received Tanreqing injection combined with azithromycin sequential treatments.Clinical effect,adverse rate,serum hs-CRP,IL-6 and TNFα were compared between the two groups.Results The total effective rate was 95.7% and 69.0% respectively in experience group and control group with significant difference（P〈0.05）.The incidence of adverse reactions was much lower in the experience group（21.7%） than in the control group（88.1%）（P〈0.05）.The levels of serum hs-CRP,IL-6 and TNF-α decreased clearly in the two groups after the treatment（P〈0.05）,but there was no significant difference between the two groups（P〈0.05）.Conclusion Tanreqing injection combined with azithromycin as sequential therapy for children with mycoplasma pneumonia can greatly improve curative effect and reduce adverse reactions.