固定剂量复合剂治疗初治涂阳肺结核的疗效分析

Analysis of the curative effect of fixed-dose combination therapy on initial smear-positive tuberculosis

目的:研究抗结核固定剂量复合剂的有效性和安全性,探索结核病有效安全的用药方案。方法:随机抽取初治涂阳性患者260例随机分为观察组132例和对照组128例,对两组患者的治疗效果和不良反应进行分析比较。结果:阴转率观察组为98.46%,对照组为90.63%,X线病灶有效率观察组为94.62%,对照组为89.11%;观察组空洞改善率87.18%,对照组91.18%。观察组治愈率(95.45%)高于对照组(87.50%)。结论:固定剂量复合剂是一种方便、高效安全的抗结核药物,值得临床应用。

Objective： To analyze the effect and safety of the anti-tuberculosis （TB） fixed-dose combination for exploring the safe and effective therapeutic regimen in the treatment of TB. Methods： 260 cases of initial smear-positive TB patients were randomly selected and divided into the observation group （132 cases） and the control group （128 cases）. Then the curative effect and adverse reactions of patients in both groups were analyzed and compared. Results. The respective negative conversion rate for patients in the observation group and the control group was 98.46% and 90.63% the effective rate of the X-ray lessions was 94.62% in the observation group and 89.11% in the con- trol group; and the improvement rate of pulmonary cavity was 87.18% in the observation group, while 91.18% in the control group. The curative rate of the observation （95.45~） was higher than that of the control group （87. 50%）. Conclusion. Fixed-dose combination, as a convenient, effieient and safe anti-TB drug, should be clinically promoted.