非小细胞肺癌化疗前后血清VEGF和MMP-9水平的对照观察

Comparison study on the changes of levels of VEGF and MMP-9 before and after chemotherapy in patients with non-small-cell lung carcinoma

目的检测非小细胞肺癌(NSCLC)化疗前后血清中血管内皮生长因子(VEGF)和基质金属蛋白酶-9(MMP-9)水平,探讨其变化规律与化疗疗效之间的关系。方法采用ELISA双抗体夹心法检测54例非小细胞肺癌患者化疗前后血清VEGF和MMP-9水平,并参照RECIST评价标准进行疗效评价。结果化疗前后血清VEGF水平无明显变化(P>0.05)。化疗后血清MMP-9水平与化疗前相比明显下降(P<0.05)。有效组化疗前后血清VEGF水平无显著变化(P>0.05)。化疗后血清MMP-9水平与化疗前相比显著降低(P<0.05)。无效组血清VEGF和MMP-9水平均无明显变化(P>0.05)。结论血清MMP-9表达水平与非小细胞肺癌的化疗疗效相关,提示MMP-9可以反映患者病情的变化,为病情的进展和预后提供依据。

Objective To observe the changes of levels of VEGF and MMP-9 before and after chemotherapy in patients with non-small-cell lung carcinoma（NSCLC） so as to explore the correlation between the change rule and therapeutic effect of chemotherapy. Methods The serum levels of VEGF and MMP-9 were detected by ELISA in 54 patients with NSCLC before and after chemotherapy, and the therapeutic effect was evaluated according to RECIST evaluation criterion. Results There were no significant changes in the serum levels of VEGF before and after chemotherapy （ P 〉 0.05 ） , however, after chemotherapy the serum levels of MMP-9 were significantly decreased, as compared with those before chemotherapy （ P 〈 0.05 ）. There were no significant differences in serum levels of VEGF in effectiveness group before and after chemotherapy （ P 〉 O. 05 ） , but the serum levels MMP-9 after chemotherapy were obviously decreased, as compared with those before chemotherapy （ P 〈 0.05）. In inefficiency group there were no significant changes in the serum levels of VEGF before and after chemotherapy （ P 〉 0.05 ） ,nor were in those of MMP-9 （ P 〉 0.05 ）. Conclusion The expression levels of serum MMP-9 are correlated with therapeutic effect of chemotherapy on NSCLC, which suggests that MMP-9 levels may reflect the patients＇ condition and maybe helpful for predicting the prognosis of patients with NSCLC.