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立体定向放射术治疗肺部小肿瘤的可行性研究 被引量:4

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摘要 目的探索用立体定向放射术(SBRT)治疗肺部小肿瘤的可行性。方法 2009年3月至2010年3月收治了38例肺部小肿瘤(<3cm)患者,采用体模固定,CT轴扫扫描。透视下,确定呼吸动度,勾画PTV。用直线加速器进行SBRT,剂量54~63Gy,分12~15次。治疗后,平均随访10个月,评价疗效和不良反应。结果 38例患者,随访8~14个月,总有效率达82.1%(CR+PR),稳定占10.7%,复发2例,占7.1%。主要不良反应是乏力、放射性肺炎1~3度、白细胞下降1~2度。结论用SBRT治疗肺部小肿瘤疗效确切,产生的不良反应轻微,肺部的毒性可接受。
出处 《河北医药》 CAS 2013年第4期533-534,共2页 Hebei Medical Journal
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  • 1Timmerman R,Papiez L,McGarry R,et al.Extracranial stereotactic radioablation:results of a PhaseⅠstudy in medically inoperable stageⅠnon-small cell lung cancer.Chest,2003,124:1946-1955.
  • 2Nagata Y,Takayama K,Matsuo Y et al.Clinical outcomes of a phaseⅠ/Ⅱstudy of 48 Gy of stereotactic body radiotherapy in 4 fractions for primary lung cancer using a stereotactic body frame.Int J Radiat Oncol Biol Phys,2005,63:1427-1431.
  • 3Mc Garry RC,Papiez L,Williams M,et al.Stereotactic body radiation therapy of early-stage non-small-cell lung carcinoma:Phase I study.Int J Radiat Oncol Biol Phys,2005,63:1010-1015.
  • 4Timmerman R,McGarry R,Yiannoutsos C,et al.Excessive toxicity when treating central tumors in a phase II study of stereotactic body radiation therapy for medically inoperable early-stage lung cancer.J Clin Oncol,2006,24:4833-4839.
  • 5Simon S,Achilles L,Fakiris J,et al.Stereotactic body radiation therapy for early-stage non-small-cell lung cancer.Experer Rev.Anticancer Ther,2008,8:87-98.
  • 6Milano MT,Katz AW,Muhs AG,et al.Aprospective pilot study of curative-intent stereotactic body radiation therapy in patients with 5 or fewer oligometastatic lesions.Cancer,2008,112:650-658.
  • 7Kyle E,Rusthoven K,Brian D,et al.Multi-Institutional Phase I/II Trial of Stereotactic Body Radiation Therapy for Lung Metastases.J Clin Oncol,2009,27:1579-1584.
  • 8Timmerman R.An Overview of Hypofractionation and Intrroduction to This Issue of Seminars in Radiation Oncology.Seminars in Radiation Oncology,2008,18:215-222.

同被引文献19

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  • 2Wisnivesky JP, Bonomi M, Henschke C, et al. Radiation therapy for the treatment of unresected stage I - ]I non - small cell lung cancer[ J ]. Chest,2005,128 : 1461 - 1467.
  • 3Valakh V, Miyamoto C, Micaily B, et al. Repeat stereotaetic body radiation therapy for patients with pulmonary malignancies who had previously received SBRT to the same or an adjacent tumor site [J]. J Cancer Res Ther,2013,9(4) :680 -685.
  • 4Kellogg RG, Straus DC, Choi M, et al. Stereotactic radiosurgery boost to the resection cavity for cerebral metastases : Report of over- all survival, complications, and corticosteroid protocol [ J ]. Surg Neurol Int ,2013,4 ( Suppl 6) : $436 - $442.
  • 5King CR, Brooks JD, Gill H, et al. Long- term outcomes from a prospective trial of stereotactic body radiotherapy for low - risk prostate cancer[ J]. Int J Radiat Oncol Biol Phys, 2012,82 ( 2 ) : 877 - 882.
  • 6Cheung PC, Yeung LT, Basrur V, et al. Accelerated hypofraetion- ation for early- stage non -small -cell lung cancer[ J]. Int J Ra- diat Oncol Biol Phys,2002,54:1014 - 1023.
  • 7Baumann P, Nyman J, l-[oyer M, et al. Outcome in a prospective phase I1 trial of medically inoperable stage I non - small - cell lung cancer patients treated with stereotactic body radiotherapy [ J]. Clin Onco1,2009 ,27 :3290 - 3296.
  • 8Fakiris AJ, MeGarry RE, Yiannoutsos CT, et al. Stereotactic body radiation therapy for early - stage non - small - cell lung carcino- ma: four - year results of a prospective phase II study [ J ]. Int J Radiat Oncol Biol Phys,2009,75:677 - 682.
  • 9朱广迎,申文江.精确放疗在可根治非小细胞肺癌治疗中的作用[J].中国肺癌杂志,2009,12(4):261-267. 被引量:6
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