美沙酮维持治疗门诊患者HCV感染状况分析

Analysis of the maintenance treatment of methadone on HCV infection patients

目的了解美沙酮维持治疗(MMT)门诊患者的丙型肝炎病毒(HCV)感染状况,为相应的疾病控制干预提供依据。方法对153名接受MMT治疗的患者采静脉血进行HCV抗体检测。结果 153例接受(MMT)的门诊患者中HCV抗体阳性率69.28%(106/153),明显高于我国普通人群的平均感染率3.20%,差异具有统计学意义(χ2=107.64,P<0.001)。MMT门诊患者男、女HCV抗体阳性率分别为66.67%(64/96)和73.68%(42/57),男、女性别差异无统计学意义(χ=0.83,P>0.05)。经注射给药的海洛因依赖者的HCV抗体阳性率89.01%(81/91),明显高于其他途径给药的海洛因依赖患者40.32%(25/62),两者比较差异具有统计学意义(χ2=41.07,P<0.001)。不同给药途径的海洛因依赖人群丙肝HCV感染男、女性别差异无统计学意义(P>0.05)。结论美沙酮维持治疗(MMT)门诊患者丙型肝炎病毒(HCV)感染率较高,尤其是注射给药的海洛因依赖者。应加强对丙型肝炎的有效防治。

Objective To understand methadone maintenance treatment（MMT） patients with outpatient service of hepatitis C virus（HCV） infection status and to provide basis for the intervention of disease control.Methods The 153 patients who acceptted the MMT treatment picked the venous blood to carry on the HCV immune body examination.Results In the MMT outpatient service patients,the HCV antibody positive rate is 69.28%（106/153）,it is higher than the general population in our country with the average infection rate of 3.20%,the difference was statistics significance（χ^2=107.64,P〈0.001）.Of the MMT outpatients,the male and female HCV antibody positive rate are 66.67%（64/96） and 73.68%（42/57）,but the difference has no statistically significant（χ^2=0.83,P〈0.05.The drug injection heroin addicts of HCV antibody positive rate 89.01%（81/91）,significantly higher than the other way to medicine heroin patients 40.32%（25/62）,both comparison difference has statistics significance（χ^2=41.07,P〈0.001）.Different methods of taking heroin dependent on the crowd HCV infection male and female gender difference has no statistically significant（P〈0.05）.Conclusion Outpatients who accept methadone maintenance treatment（MMT） with hepatitis C（HCV） had a high infection rate,especially injection drug delivery of heroin dependent patients.Effective prevention of HCV should be strengthened.