吗啡泵治疗重度癌痛的疗效分析

Curative Effect Analysis of Morphine Pump in the Treatment of Severe Pain

目的观察重度癌性疼痛患者应用吗啡泵快速镇痛的疗效。方法收集70例NRS>6分的重度癌性疼痛患者,随机分为吗啡泵组(使用持续皮下注射吗啡治疗)与酸羟考酮组(使用口服盐酸羟考酮治疗)。观察两组患者镇痛疗效、NRS评分、镇痛维持时间、剂量稳定时间。结果吗啡泵组治疗后NRS评分为(2.0±1.2)分,盐酸羟考酮组治疗后NRS评分为(2.1±1.3)分,两者无统计学差异,但经治疗后两组的NRS评分均明显降低,与治疗前相比有统计学差异。而吗啡泵组的剂量稳定天数约(2.7±1.8)天,每天平均镇痛维持时间约(22.5±0.5)小时。结论使用持续皮下注射吗啡治疗可明显改善重度癌痛患者的疼痛,并且从剂量稳定天数和每天平均镇痛维持时间方面较盐酸羟考酮好。

Objective To observe the curative effect of rapid application of morphine analgesia pump on patients with severe cancer pain. Methods 70 cases of severe cancer pain patients with NRS 〉6 were randomly divided into the morphine pump group （received continuous subcutaneous injection） and the oxycodone hydrochloride group （received oral oxycodone hydrochloride therapy）. The analgesic effect, NRS scores, analgesia maintaining time and dosage stable time of the two groups were observed. Results After the treatment, the NRS score was （2.0 ±1.2） in the morphine pump group and （2.1 ± 1.3） in the oxycodone hydrochloride group, without statistical difference. However, the NRS scores were significantly lower after treatment in both groups. The dosage stable time was about （2.7 ±1.8） days in the morphine pump group, and the daily average analgesia maintaining time was about （22.5± 0.5） hours. Conclusions Continuous subcutaneous injection of morphine treatment could obviously improve the severe pain of cancer patients, and it was slightly better than oxycodone hydrochloride on aspects of dosage stable time and the daily average duration of postoperative analgesia.