舒血宁注射液治疗老年缺血性脑血管病的机制及前瞻性研究

The Mechanism and Prospective Study on Shuxuening Injection in the Treatment of Senile Ischemic Cerebrovascular Disease

目的探讨舒血宁注射液治疗老年缺血性脑血管病的临床机制,并对疗效进行前瞻性研究。方法选取我院收治的78例老年脑梗死患者,将其随机分为观察组和对照组各39例,对照组采用常规方法治疗,观察组在对照组基础上加用舒血宁注射液,比较两组患者治疗总有效率及治疗前后血液流变学各项指标。结果观察组治疗总有效为94.9%,对照组为71.8%,两组比较差异有统计学意义(P<0.01),且观察组治疗后血浆粘度、全血粘度、红细胞变形指数、红细胞聚集指数下降更为明显,与对照组治疗后比较差异有统计学意义(P<0.01)。结论舒血宁注射液可明显改善老年脑梗死患者血液流变学各项指标,对老年缺血性脑血管病疗效确切,且安全可靠,值得临床推广。

Objective To explore the clinical mechanism of shuxuening injection in the treatment of senile ischemic cerebrovascular disease, and to study its efficacy prospectively. Methods Seventy-eight cases of elderly patients with ischemic cerebrovascular disease in our hospital were selected and randomly divided into the observation group and the control group, with 39 cases in each group. The control group was given conventional treatment, while the observation group received shuxuening injection on the basis of conventional treatment. The total efficiency and the indices of blood before and after treatment of two groups were compared. Results The total effective rate was 94.9% in the observation group and 71.8% in the control group. The difference between the two groups was statistically significant （P 〈0. 01）. After treatment, plasma viscosity, whole blood viscosity, erythrocyte deformation index and erythrocyte aggregation index of the observation group decreased more obviously, and the difference compared with the control group was statistically significant （P 〈0.01）. Conclusions Shuxuening injection is effective for elderly patients with ischemic cerebrovascular disease, as it can significantly improve the indices of blood of elderly patients with cerebral infarction. It is safe, reliable, and worthy of clinical application.