伴高血压病的脑梗死患者血清基质金属蛋白酶-9水平变化及意义

Measurement of Serum MMP-9 level and its clinical value in acute cerebral infarction patients with essential hypertension

目的探讨伴高血压急性脑梗死患者血清基质金属蛋白酶-9(MMP-9)水平变化及意义。方法选择临床上发病3天内入院的伴有原发性高血压病的急性前循环脑梗死患者65例,不伴原发性高血压病的急性前循环脑梗死的患者43例,原发性高血压病患者30例,健康对照组30例,采集空腹静脉血。用ELISA法检测其血清MMP-9水平。结果伴有原发性高血压病急性脑梗死组患者血清MMP-9水平(316.18±52.26ng/ml)明显高于其他三组(均P<0.01),不伴原发性高血压病的脑梗死组患者血清MMP-9水平(287.65±48.83ng/ml)明显高于原发性高血压病组(206.82±44.22ng/ml)和健康对照组(112.16±36.28ng/ml)(均P<0.01)。原发性高血压组患者血清MMP-9水平明显高于对照组(P<0.01)。结论高血压病患者及脑梗死患者血清MMP-9均有明显增高,血清MMP-9的活性增强可能是高血压导致脑梗死发生的机制之一,血清MMP-9可能在高血压脑梗死患者的发病及继发的病理损害中发挥更为重要的作用。血清MMP-9可以作为高血压病患者脑梗死前的预警指标。

Objective To investigate serum Matrix metalloproteinase-9 （MMP-9） level in acute cerebral infarction patients with or without essential hypertension and patients with essential hypertension. Methods 108 patients with acute cerebral infarction within 3 days,30 patients with essential hypertension and 30 normal health control were enrolled. Venous blood was taken for MMP-9 determination. To compare the serum MMP-9 levels between the four groups. Results Serum MMP-9 levels in patients with acute cerebral infarction with essential hypertension was significantly higher than other 3 groups （respectively, P〈0.05）.Serum MMP-9 levels in patients with essential hypertension was significantly higher than the normal health control. Conclusion MMP-9 may play a very important role in the pathogenesis and secondary brain injury in the acute cerebral infarction with essential hypertension. Serum MMP-9 may be an early warning indicator before cerebral infarction for essential hypertension patients.