Podoplanin和CD34在宫颈癌中的表达及其意义

Expression of Podoplanin and CD34 In invasive carcinoma of cervix

目的:研究Podoplanin、CD34在宫颈癌中的表达及其意义。方法:用免疫组化方法检测53例早期宫颈癌ICC和15例癌旁正常宫颈上皮(NEC)中Podoplanin和CD34表达情况。结果:宫颈癌组织中Podoplanin和CD34阳性表达率分别为90.5%、100%。Podoplanin在宫颈癌旁正常宫颈组织未发现阳性表达。宫颈癌组织Podoplanin和CD34表达呈正相关。(χ2=23.432,P<0.05),二者的联合表达与淋巴结转移及预后密切相关(P<0.05)。结论:Podoplanin和CD34可能在宫颈癌的发生发展过程中起关键作用,二者在肿瘤转移过程中密切相关。检测其表达水平,对于宫颈癌的诊断、恶性程度及预后的判断有一定价值。

Objective To investigate the expressions of Podoplanin and CD34 in invasive carcinoma of cervix and explore their relationship to clinical biological behavior.Method Expression of Podoplanin and CD34 in 53 cases of early invasive carcinoma of cervix and 15 cases of normal cervical epithelium remote from tumor were detected by immunohistochemistry SP method during Jan 1996 to Dec 1998.Results 1.The positive expression rate of Podoplanin and CD34 in early invasive carcinoma of cervix was 90.5 % and 100% respectively.No expression of Podoplanin was detected in normal cervical epithelium（NEC） remote from tumor.2.In ICC Podoplanin was positively related to expression of CD34（χ2=23.432,P0.05）.Associated expression of Podoplanin and CD34 was closely correlated to lymph node metastasis and prognosis（P0.05）.Conclusion Podoplanin and CD34 may play a pivotal role in tumor genesis and tumor progression in cervical carcinoma and they have intimate relation in tumor metastasis.Detection of their expression may be valuable for diagnosing cervical carcinoma,degree of malignancy and prognosis.