P-选择素与组织蛋白酶D在肺癌组织中的表达与临床病理的相关性研究

A clinical study on the expression of cahthepsin D and P selectin in human lung cancer

目的研究患者肺癌组织中P-选择素、组织蛋白酶D(CD)的表达,进而探讨它们与肺癌临床病理的关系。方法采用免疫组化法检测58例患者肺癌组织中P-选择素、组织蛋白酶D的表达水平。结果 P-选择素和CD在肺癌组织中的阳性率分别为43.1%(25/58)和53.5%(31/58),P-选择素与淋巴结转移有关(P﹤0.05),与病理类型、病理分级、病理分期、5年存活率无关(P﹥0.05)。CD表达与病理分期、淋巴结转移、5年存活率有关(P﹤0.05),与病理类型、病理分级无关(P﹥0.05)。两个指标均表达阳性的肺癌患者5年存活率为31.3%(5/16),显著低于阴性患者5年存活率81.8%(9/11),P﹤0.05。结论共同检测P-选择素和CD水平,对于判断肺癌患者的预后有重要意义。

Objective To study the expression of cahthepsin D and P selectin in patients with lung cancer,in order to investigate its relationship with clinicopathology.Methods Immunhistochemistry was applied to detect the expression of cahthepsin D and P selectin in 58 lung cancer specimens.Results The positive rates of P selectin and cahthepsin D were 43.1% and 53.5%,respectively.P selectin expression in lung cancer was positively correlated with the lymph node metastasis（P﹤0.05）,and was negatively correlated with TNM stage,tumor differentiated degree,pathologic type,5 years survival rate of the patients（P﹥0.05）.CD expression in lung cancer was positively correlated with the TNM stage,lymph node metastasis and 5 years survival rate of the patient（P﹤0.05）,and was negatively correlated with tumor differentiated degree and pathologic type（P﹥0.05）.5-year survival rate in lung cancer patients with the positive expression of P selectin and cathepsin D（31.3%） was significantly lower than that in negative expression patients（81.8%,P﹤0.05）.Conclusion Combination measurement of P selectin and Cathepsin D can be used to evaluate the lymph node metastasis and prognosis of lung cancer.