ROC曲线对比分析超敏cTnT和cTnT对心肌梗死的诊断价值

ROC curves contrast analysis cTnT and cTnT allergic the diagnostic value of myocardial infarction

目的:通过对心肌梗死与稳定型心绞痛患者绘制超敏肌钙蛋白T(cTnT)和肌钙蛋白T(cTnT)ROC曲线,对比两种方法的优越性。方法:采用电化学免疫发光法测定心梗组、稳定型心绞痛组与健康对照组的血清超敏cTnT和cTnT,并对超敏cTnT和cTnT进行统计学和ROC分析。结果:超敏cTnT在心肌梗死诊断中的敏感度82.6%,特异度92.3%,阳性结果预测值97.9%,诊断临界值0.035ng/ml;cTnT的敏感度78.3%,特异度84.6%,阳性结果预测值94.4%,诊断临界值为0.079ng/ml。超敏cTnT的ROC曲线下面积AUC=0.916,cTnT的AUC=0.856。结论:血清超敏cTnT是诊断急性心肌梗死灵敏而特异的诊断指标,明显优于cTnT,可作为诊断急性心肌梗死的辅助诊断指标,同时能够鉴别心肌梗死和稳定型心绞痛。

Objective： Myocardial infarction in patients with stable angina pectoris draw the ROC curve of high-sensitivity troponin T （cTnT） and troponin T （cTnT）, the superiority of the comparison of the two methods. Methods： Electrochemical immunoassay luminescence determination of the MI group, stable angina group and the healthy control group, serum high sensitivity cTnT and cTnT, and high-sensitivity cTnT and eTnT statistics and ROC analysis. Results：Finally ultra sensitive cTnT diagnoses at the cardiac arrest the sensitivity was 82.6 %, the pe culiarity was 92.3 %, the masculine result forecast value was 97.9 %, the diagnosis marginal value was 0. 035ng/ml; The cTnT sensitivity was 78. 3%, the peculiarity was 84.6%, the masculine result forecast value was 94.4%, the diagnosis marginal value was 0. 079ng/ml. Under ultra sensitive cTnT ROC curve area AUC= 0. 916, cTnT AUC = 0. 856% Conclusions： Serum high sensitivity cTnT diagnosis of acute myocardial infarction sensitive and specific diagnostic indicators, significantly better than cTnT can be used as a diagnostic marker in the diagnosis of acute myocardial infarction, at the same time be able to identify myocardial infarction and stable angina pectoris.