血液病患者预防性血小板输注阈值的比较

Comparison of Prophylactic Platelet Transfusions Threshod in Patients with Hematological Diseases

目的探讨预防性血小板输注阈值对血液病患者的影响。方法将确诊为血液系统疾病且出血程度为0级的患者分为A、B两组,A组:血小板<10×109/L,B组:血小板(10～20)×109/L,比较两组患者在输注不同剂量血小板后,出血改善及输血不良反应情况。结果 A组患者输注次数和输注量明显低于B组,而两组间出血发生率的差异无统计学意义(P>0.05),但输血不良反应的发生率A组略低于B组。结论对病情稳定且无明显危险因素的血液病患者,采用10×109/L作为预防性血小板输注的阈值是安全的。

Objective To investigate the effect of different prophylacticplatelet transfusion threshod in patients with hematologic diseases. Methods The patients diagnosed with hematologic diseases and admitted with bleeding severity of grade 0 were divided into group A and group B. Group A： platelets count 〈10×10^9/L, Group B： platelets count （10 20）×10^9/ L. To compare the situation of two groups in infusion of different dose of platelets in hemorrhage improvement and adverse transfusion reaction. Results The times and numbers of platelet transfusion in group A were significantly low- er than those in group B. While there was no statistical difference in the incidence of bleeding（P〉0.05）. The rate of adverse transfusion reactions in group A was slightly lower than those in group B. Conclusion To stable patients with hematologic diseases and with no obvious risk factors, using a 10×10^9/ L trigger as a prophylactic platelet transfusion threshold is safe.