正压通气治疗对阻塞性睡眠呼吸暂停综合征夜间心律失常的作用

The Effects of CPAP Therapy on Arrhythmia in Patients with OSAS

目的 :探讨阻塞性睡眠呼吸暂停综合征 (OSAS)患者病情严重程度与夜间心律失常的关系 ,以及经鼻持续气道内正压 (n CPAP)通气治疗对心律失常的作用。方法 :10 1例阻塞性睡眠呼吸暂停综合征患者按呼吸紊乱指数分轻、中、重三组 ,观察夜间平均心率变化、最大心率变化、最慢心率、最快心率及心律失常累计时间 ,比较组间差异性 ,并对 16例患者进行了n CPAP治疗前后各项参数的比较。结果 :夜间心率变化和夜间心律失常随OSAS病情加重而明显加重。轻度与中重度患者组间有显著差异 ;n CPAP治疗后夜间心率变化和心律失常均明显改善。结论 :OSAS夜间心律失常随病情程度而加重 ;n CPAS治疗不仅能消除呼吸紊乱、改善夜间缺氧 ,而且使夜间心律失常明显减轻。

Objective:To investigate the relationship between the severity of OSAS and nocturnal arrhythmia in patients with OSAS and the effectts of n CPAP therapy on nocturnal arrhythmia.Methds:101patients of OSAS were divided into mild,moderate and severe groups according to the Respiratory Disorder Index (with the RDI of 5_30/h,30_60/h,>60/h respectively). The following nocturnal parameters were monitored:heart rate variance;duration of bradytachycardia;lowest heart rate and highest heart rate. 16 patients were treated with n CPAP and their parameters were compared before and ofter treatment. Results:The arrhythmia in moderate and severe OSAS group were more serious than that of the mild patients. n_CPAP therapy could improve the nocturnal heart rate variation and arrhythmia. Conclution:The severity of nocturnal arrhythmia is correlated with the severity of OSAS. n CPAP treatment not only meliorate breathing disorder and hyoxemia,but also improve nocturnal arrhythmia in patients with OSAS.