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小窝蛋白1与肿瘤的关系

Caveolin-1 with tumour
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摘要 小窝蛋白是正常位于哺乳动物细胞膜内表面,蛋白质序列高度保守的一组蛋白,它包括小窝蛋白1、小窝蛋白2、小窝蛋白3和小窝蛋白4.它们与细胞的胞吞、脂质的代谢,以及细胞信号转导等有密切的联系.近年来发现,不仅肿瘤细胞小窝蛋白1表达水平与肿瘤的生长和转移有关,而且在肿瘤的间质细胞小窝蛋白1表达的水平也与多种肿瘤的转移有关. Caveolin are a family that proteins are highly conserved and located at the mammalian plasma membrane.They include four isoforms：Cav-1,Cav-2,Cav-3 and Cav-4.Caveolin proteins are implicated in endocytosis,lipid metabolism and cellular signaling.There is recent evidence that Cav-1 expression levels in tumour have been associated with tumour growth and metastasis,stromal car-1 expression downregulated have been also associated with mutli-tumor metastasis.
作者 侯辉 耿小平
机构地区 安徽医科大学第二附属医院普外科一病区
出处 《国际外科学杂志》 2013年第6期398-401,共4页 International Journal of Surgery
关键词 小窝蛋白1 肿瘤转移 膜蛋白质类 生长 Cav- 1 Neoplasm metastasis Membrane proteins Growth
分类号 R730 [医药卫生—肿瘤]
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参考文献31

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国际外科学杂志
2013年 第6期

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