水果摄入对胃癌发生影响的Meta分析

Fruit intake and gastric cancer： a Meta-analysis study

目的 通过Meta分析研究水果摄入对胃癌发生的影响.方法 通过Medline、Pubmed、Ovid数据库及万方数据库、中国期刊全文数据库、重庆维普数据库等工具检索2001年1月至2012年10月国内外发表的关于水果摄入与胃癌关系的队列研究,收集文献资料.采用Meta分析的方法对数据进行分析,根据异质性采用不同的模型对检索文献的相对危险度（RR）值及其95％可信区间（CI）值进行合并,并根据地区、随访时间、调整因素进行亚组分析.结果 共纳入队列研究文献7篇,随访人数1 173 859例,其中胃癌患者3679例；总合并效应量为0.89（95％ CI：0.78 ～ 1.01）,提示水果摄入对胃癌的发生保护性作用不具有独立性；亚组分析结果表明,随访时间≥10年的合并效应量为0.94（95％ CI：0.85 ～0.99）,调整了年龄、吸烟、饮酒等生活习惯因素的效应量为0.81（95％CI：0.54 ～0.99）,提示排除了不良生活习惯等因素的影响,水果的摄入对胃癌的发生具有保护作用.结论 水果摄入对胃癌发生具有抑制作用,建议在饮食中适当增加水果以预防胃癌的发生.

Objective To assess the relationship between fruit intake and gastric cancer.Methods Articles published during January 2001 and October 2012 that assessed the relationship between fruit intake and gastric cancer were searched on PubMed,Ovid and Willey database.Adjusted relative risk （RR） and 95％ confidence intervals （CI） were calculated by using fixed-effect or random-effect model.Variants of subgroup analysis included living regions,followup duration,and adjusted factors.Results A total of 3679 gastric cancer patients and 1 173 859 subjects from 7 prospective cohorts were included in this metaanalysis,and the pooled RR was 0.89 （95％ CI：0.78-1.01）.In the subgroup analysis,the pooled RR in the 10-year followup group was 0.94 （95％ CI：0.85-0.99） before age,cigarette smoking and alcohol drinking were adjusted （RR =0.81,95％ CI：0.54-0.99）.Conclusion Fruit intake may prevent the development of gastric cancer.