体内真菌毒素生物标记物检测方法的研究进展

Research Progress for Detection Techniques of Mycotoxins Biomarkers In Vivo

真菌毒素是一些真菌在生长过程中产生的有毒次级代谢产物,广泛污染农作物、食品和饲料等,由于多数真菌毒素具有很强的毒性,可致癌、致畸和致突变,人和动物通过饮食可能暴露于不同的真菌毒素,对人和动物的健康构成了极大的威害。本文以人和动物血液、尿液、胆汁、乳汁和粪便中真菌毒素的原形及其代谢物作为真菌毒素生物标记物,通过测定其含量来评价人和动物暴露于真菌毒素的频率和水平。本文归纳体内常见真菌毒素生物标记物的种类,分析其对人和动物的危害性,并综述体内真菌毒素生物标记物检测的研究现状。

Mycotoxins are secondary metabolites produced by certain genera of toxigenic fungus and frequently occur in food worldwide.Humans and animals can be simultaneously exposed to different mycotoxins through the diet.As most mycotoxins are highly toxic,carcinogenic,teratogenic and mutagenic,they have posed grave health threats to consumers.Determination of mycotoxins and their main metabolites in blood,urine,bile,milk or faeces can serve as biomarkers and can facilitate effective exposure assessment,crucial to estimate mycotoxin related dis ease risk.According to reason mentioned above,the study of metabolism and evaluations of mycotoxins in biologi cal fluids have been paid increasing attention since the results may offer valuable indications on the real risk for consumers.Therefore,it is important to develop proper analytical methods for the rapid quantitative and qualita tive measurement of mycotoxins and key metabolites in vivo.This paper reviewed some biomarkers and their harm to animals and humans,systematically summarized the research progress of analytical methods and prospected the development trends.