斑马鱼在药物早期毒性筛选中的应用进展

Progress of application of zebrafish in early drug toxicology screening

斑马鱼作为一种较理想的模式生物早在上世纪便应用于环境毒性的评价,并得到了世界的公认。但其应用于药物毒理学却相对比较滞后。近些年来随着对斑马鱼的深入研究以及其本身具有的优势,得到了药物毒理学家的重视。本文对斑马鱼应用于药物早期筛选的优势及存在的不足进行了简单概述,并对其近年来的在早筛中的应用进展进行了综述。

Zebrafish, as an ideal model organism, was applied to the evaluation of the environmental toxic- ity in the last century and well recognized by the world. However, its application in drug toxicology study was rela- tively behind. In recent years, with the in-depth studies of zebrafish as well as the advantage of zebrafish itself, it has got more attention of drug toxicologists. The advantages and shortcomings of using zebrafish in early drug screening and the development in recent years are reviewed in this paper.