培美曲塞化疗联合放疗治疗肺腺癌脑转移的临床观察

Clinical analysis of pemetrexed chemotherapy combined with radiotherapy in brain metastases of lung adenocarcinoma

目的观察培美曲塞化疗联合放疗在肺腺癌脑转移患者治疗中的临床疗效。方法选择病理诊断为肺腺癌并且出现脑转移的患者资料进行回顾性诊断分析，采用分层区组随机化方法分为观察组26例和对照组25例，观察组采用培美曲塞化疗联合放疗，对照组采用单纯放疗，对比观察患者的颅内转移瘤、生活质量、近期疗效、不良反应和患者的生存期情况。结果患者的近期疗效和生存质量明显改善，相比差异显著，不良反应轻微，生存期差异不显著。结论培美曲塞联合放射治疗应用于肺腺癌脑转移的治疗中，有效改善患者的近期疗效与生活质量，不良反应轻微，在肺腺癌脑转移的治疗中，具有较大的推广应用价值。

Objective To observe the clinical effects of pemetrexed chemotherapy combined with radiotherapy in brain metastases of lung adenocarcinoma patients. Methods The data of lung adenocar- einoma patients with brain metastases were conducted retrospectively diagnostic analysis, and they were stratified randomized divided into the observation group （26 cases） and the control group （25 cases）. The observation group was treated with pemetrexed chemotherapy combined with radiotherapy; the control group was treated with radiotherapy alone. Brain metastases, quality of life, short-term efficacy, adverse reactions, and patients＇ survival period were observed. Results The efficacy and quality of life of patients in the observation group were improved significantly than those of the control group, and adverse reactions were mild, the survival period was not significant between two groups. Conclusions Pemetrexed in combina- tion with radiation therapy for the treatment of brain metastases from lung adenocareinoma can effectively improve the short-term efficacy and quality of life of patients, and the adverse reactions are mild, it possess great application value in the treatment of brain metastases of lung adenocarcinoma.