摘要
目的观察左西孟旦治疗失代偿性心力衰竭患者的临床效果及不良反应。方法选择我院心内科应用左西孟旦治疗的63例失代偿性心力衰竭患者，所有患者在常规优化抗心力衰竭治疗的基础上，应用左西孟旦治疗。观察左西孟旦治疗后的临床疗效，测定用药前和用药后第7天血浆氨基末端B型利钠肽前体（NT-ProBNP），并心脏超声检测左心室射血分数（LVEF），记录用药前和用药后7d内24h尿量。观察患者用药期间及用药后不良反应及恢复情况，并记录护理要点。结果与用药前相比，患者应用左西孟旦的第1个24h内尿量显著增加，在观察的7d时间内，此效应持续存在。用药后第7天，LVEF增加，与治疗前比较差异有统计学意义，NT-ProBNP显著降低。应用左西孟旦治疗总体有效率为84．1％，总的不良事件发生率为34．9％。结论左西孟旦治疗失代偿性心力衰竭患者，可明显改善其心功能，降低BNP；同时有较高的不良反应发生率，因此用药过程中需严密监护，及时发现并纠正不良反应，保证治疗效果的同时，更好地保证患者的安全。
Objective To observe levosimendan-induced hemodynamic improvement of chronic decompensated heart failure patients and adverse effects, and sum up the nursing experience of Levosimen- dan. Methods Sixty-three patients with decompensated heart failure were treated with Levosimendan, based on optimized conventional treatment for heart failure. Aminoterminal probrain natriuretic peptide （NT-proBNP） and left ventricle ejective fraction （LVEF） were measured at baseline and one week after Levosimendan administration. In addition, we summarized the clinical observation, adverse effects and nursing experiences of treatment with Levosimendan in decompensated heart failure patients. Results Levosi- mendan increased 24-hour urine output in patients at the first day after treatment. This effect of levosimendan persisted for 7 days at least. We observed an improvement in LYEF and a reduction of NT-pro-BNP at 7 days after the initiation of levosimendan treatment. Clinical efficiency of levosimendan in patients was 84.1% in this study. Twenty two patients（34.9%） experienced different adverse events. Conclusions Levosimendan therapy can improve cardiac function and reduce BNP in patients with decompensated heart failure. The rate of adverse effects of Levosimendan is high. It is important to enhance therapy effect by careful nursing and observing variety state during treatment with Levosimendan. These data will be useful for the nursing care of Levosimendan in clinical practice.
出处
《中国实用护理杂志》
北大核心
2013年第20期38-41,共4页
Chinese Journal of Practical Nursing
