PPARγ基因C161T多态性与中国汉族人动脉粥样硬化血栓形成性梗死的相关性

Conelafion between PPART CI61T polynwphisrm mid atherothronlmtic infraction in a Chinese Han population

目的探讨中国汉族人群过氧化物酶体增殖物激活受体γ（peroxisome proliferator—activated receptor γ，PPAR-γ）基因C161T多态性与动脉粥样硬化血栓形成性脑梗死（atherothrombotic infarction，ATI）的关系。方法纳入ATI患者（ATI组）和同期无卒中、短暂性脑缺血发作和心肌梗死史的体检者（对照组），采用聚合酶链反应一限制性片段长度多态性方法检测PPAR~基因C161T基因型，比较ATI组与对照组基因型和等位基因频率。结果共纳入ATI患者112例和对照者112例。ATI组年龄[（67．9±11．73）岁对（66．5±10．35）岁；t=0．386，P=0．701]和男性的构成比（61．61％对58．04％；y。=0．297，P=0．586）与对照组无显著性差异。ATI组高血压（59．82％对44．62％；Y。=5．171，P=0．023）和2型糖尿病（26．79％对9．82％；矿=10．778，P：0．001）患者构成比以及体质指数[（25．13±1．86）kj对（24．11±1．81）k耐；卢3．543，P=0．001]、收缩压[（158．84±20．15）millHg对（135．82±19．58）millHg，1FilmHg=0．133kPa；扣7．350，P=0．000]、舒张压[（76．90±13．64）rnlTlHg对（68．90±8．52）millHg；户4．374，P=0．000]和空腹血糖[（6．523±2．831）mmol／L对（5．706±2．177）mmol／L；卢2．026，P=0．044]均显著性高于对照组。ATI组CC、CT和TT基因型频率分别为77．7％、17．0％和5．4％，对照组分别为69．6％、22．3％和8．O％，两组间无显著性差异（X2=1．909，P=0．385）。ATI组C和T等位基因频率分别为86．2％和13．8％，对照组分别为80．8％和19．2％，两组间亦无显著性差异（矿=2．331，P=0．127）。结论中国汉族人群PPAR＇,／基因C161T多态性可能与ATI发病无关。

Objective To investigate the relationship between the C161T polymorphisms in peroxisome proliferators-aetivated receptor 5＇ （PPAR/） lae and atherothrombotic infarction （ATI） in a Chinese Han population. Methods The patients with atherothrombotic infarction and controls, who without histories of stroke, transient ischemic attack and myocardial infarction were enrolled. Genotypes of the PPAR/ C161T polymorphisms were determined using the polymerase chain reaction-restriction fragment length polymorphism. The frequencies of notype and allele in patients with ATI and controls were compared. Results A total of 112 ATI patients and 112 controls were enrolled. There were no significant differences in the age （67. 9± 11.73 years vs. 66. 5 ± 10. 35 years; t =0. 386, P =0. 701） and the proportion of male （61.61% vs. 58. 04% ; X2 =0. 297, P =0. 586） in the ATI group and the control group. The proportions of hypertension （59. 82% vs. 44. 62% ; X2 = 5. 171, P = 0. 023）, type 2 diabetes mellitus （26. 79% vs. 9. 82% ; X2 = 10. 778, P = 0. 001 ） in the ATI goup were significantly higher than those in the control group. Body mass index （25. 13± 1.86 kg/m2 vs. 24. 11 ± 1.81 kg/m2; t = 3. 543, P= 0. 001）, systolic pressure （158.84 ± 20. 15 rnm Hgvs. 135.82 ± 19. 58 mm Hg; t = 7. 350, P = 0. 000）, diastolic pressure （76. 90 ± 13.64 mm Hgvs. 68. 90 ±8. 52 mm Hg; t =4. 374, P =0. 000） and the level of fasting blood glucose （6. 523 ±2. 831 mmol/L vs. 5. 706 ± 2. 177 mmol/L; t =2. 026, P = 0. 044） in the ATI group were significantly higher than those in the control group. The genotype frequencies of CC, CT and TT in the ATI group were 77. 7%, 17. 0% and 5.4%, respectively, and in the control group were 69.6%, 22. 3% and 8.0%, respectively. There were no siificant difference between the two groups 0（2 = 1. 909, P =0. 385）. The allele frequencies of C and T in the ATI group were 86. 2% and 13.8%, respectively, and in the control group were 80. 8% and 19. 2%, respectively. There were no significant difference between the two groups x2 =2. 331, P=0. 127）. Conclusions PPAR C161T polymorphisms may be not associated with the onset of ATI in a Chinese Ham population.