微小RNA：缺血性卒中的治疗靶点

ncroRNAs： therapeutic tarts for ischemic stroke

微小RNA（microRNA，miRNA）是一类长度为21～25nt的非编码小RNA，可与其靶基因的3端非编码区互补结合，直接降解靶基因或抑制其编码蛋白质的翻译，广泛参与发育、代谢、凋亡以及多种疾病过程。研究表明，miRNA在缺血性卒中的发生和发展过程中发挥着重要作用，并参与了卒中后的保护和修复机制的调控。

microRNAs （miRNAs） are a class of small non-coding RNAs （length 21 to 25 m）. They can complement and bind to 3＇ non-coding region of their target genes, directly deffade target es or inhibit the translation of encoding proteins, and extensively participate in development, metabolism, apoptosis, and a variety of disease processes. Studies have shown that miRNAs play important roles in the occurrence and development of ischemic stroke, and participate in post-stroke protection and regulation of repair mechanisms.