MHC结构与功能的研究进展

Progress in Study on MHC Structure and Function

MHC分子首先作为主要组织相容性抗原被发现 ,进而依此命名。随着其抗原结合分子及T细胞信使生物学功能本质的揭示 ,MHC为什么是主要组织相容性抗原的谜底就昭然于世。约10年前 ,MHC分子的抗原结合骨架结构首次被阐明 ,关于MHC结构与功能的研究就进入了一个方兴未艾的崭新时代 ,并在这一领域中取得了许多可喜的成果。对此 。

The MHC molecules were first discovered as major histocompatibility antigens. When their essential biological function as antigen-binding molecules and informers for T cells was unveiled, an explanation of why MHC also acts as major histocompatibility antigens was provided. When the antigen-binding cleft of MHC molecules was firstly clarified more than 10 years ago, the study of MHC structure and function has stepped into a prosperous new era, and many achievements have in this area have been achieved. This paper summarized the exciting progress in study on MHC structure and function in recent years.