非糖尿病的高血压患者非酒精性脂肪肝与多代谢异常

Non-alcoholic fatty liver disease(NAFLD) and multiple metabolic disorders in non-diabetic essential hypertension

目的:探讨非糖尿病的原发性高血压(EH)患者伴发非酒精性脂肪性肝病(NAFLD)的患病率及与多代谢异常的关系。方法:947例非糖尿病的EH患者住院期间经腹部超声检查和采集病史筛查NAFLD,观察其患病率、肝功酶学异常的比例及其与多代谢异常的关系。结果:非糖尿病的EH患者伴发NAFLD患者发生率为34.5%(327/947)。NAFLD组男性,冠心病,MS的发生率,BMI,血清总胆固醇,血尿酸,ALT水平均高于非NAFLD组(P<0.05)。多因素Logistic回归分析中,男性,冠心病,BMI,总胆固醇,尿酸水平是非糖尿病的EH患者NAFLD的独立危险因素。结论:非糖尿病EH伴NAFLD的患者与MS等多代谢异常密切相关,男性和冠心病是其独立危险因素。

Objective ： To investigate the incidence of NAFLD in non - diabetic essential hypertension and the relation between NAFLD and multiple metabolic disorders. Methods： Nine hundred and forty - seven patients with non- diabetic EH were enrolled this study. All patients had ultrasound screening for fatty liver. Results： Among 947 recruited patients, 34.5% （ 327/947 ） had fatty liver by ultrasonography. In non - diabetic EH co - existed with NAFLD group,prevalence of male, coronary artery disease, metabolic syndrome, BMI and the levels of TC, UA and ALT were significantly higher than those in the EH alone （P 〈 0.05 ）. By multivariable logistic regression analysis, male incidence, coronary artery disease, BMI and the levels of TC and UA were risk factors in NAFLD patients with non - diabetic EH. Conclusion： NAFLD was more prevalent in patients with non - diabetic EH complicated with metabolic syndrome and multiple metabolic disorders. Male and coronary artery disease were risk factors for NAFLD.